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The effects of amiodarone or dexamethasone on diclofenac-induced hepatotoxicity: Implications of P450s and SIRT1/Nrf2/NF-κb signaling pathways.

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Title: The effects of amiodarone or dexamethasone on diclofenac-induced hepatotoxicity: Implications of P450s and SIRT1/Nrf2/NF-κb signaling pathways.
Authors: Khatab LA; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt. Electronic address: LamiaaAAkhatab@pharm.dmu.edu.eg., Abdel-Raheem IT; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt., Ghoneim AI; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt; Department of Clinical Pharmacy & Pharmacy Practice, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt. Electronic address: asser.ghoneim@pharm.dmu.edu.eg.
Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2026 Jun; Vol. 54 (6), pp. 100317. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Khatab+LA%22">Khatab LA</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt. Electronic address: LamiaaAAkhatab@pharm.dmu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Abdel-Raheem+IT%22">Abdel-Raheem IT</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.<br /><searchLink fieldCode="AU" term="%22Ghoneim+AI%22">Ghoneim AI</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt; Department of Clinical Pharmacy & Pharmacy Practice, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt. Electronic address: asser.ghoneim@pharm.dmu.edu.eg.
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      – Type: doi
        Value: 10.1016/j.dmd.2026.100317
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      – Code: eng
        Text: English
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      – TitleFull: The effects of amiodarone or dexamethasone on diclofenac-induced hepatotoxicity: Implications of P450s and SIRT1/Nrf2/NF-κb signaling pathways.
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            NameFull: Khatab LA
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            NameFull: Abdel-Raheem IT
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            NameFull: Ghoneim AI
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              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
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              Value: 54
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            – TitleFull: Drug metabolism and disposition: the biological fate of chemicals
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