A synaptic mechanism for encoding the learned value of action-derived safety.

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Title: A synaptic mechanism for encoding the learned value of action-derived safety.
Authors: Macdonald EE; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA. emma.macdonald@nih.gov., Ma J; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China., Liu D; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA., Yu K; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA., Walker RA; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA., Authement ME; Section on Neurobiology of Compulsive Behaviors, National Institute of Mental Health, Bethesda, MD, USA., Leng Y; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA., Goldbach HC; Section on Neurobiology of Compulsive Behaviors, National Institute of Mental Health, Bethesda, MD, USA., Li G; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China., Li Y; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China., Alvarez VA; Section on Neurobiology of Compulsive Behaviors, National Institute of Mental Health, Bethesda, MD, USA., Averbeck BB; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, USA. averbeckbb@mail.nih.gov., Penzo MA; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA. mario.penzo@nih.gov.
Source: Nature communications [Nat Commun] 2026 Jun 04; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-73906-3