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A synaptic mechanism for encoding the learned value of action-derived safety.

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Title: A synaptic mechanism for encoding the learned value of action-derived safety.
Authors: Macdonald EE; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA. emma.macdonald@nih.gov., Ma J; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China., Liu D; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA., Yu K; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA., Walker RA; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA., Authement ME; Section on Neurobiology of Compulsive Behaviors, National Institute of Mental Health, Bethesda, MD, USA., Leng Y; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA., Goldbach HC; Section on Neurobiology of Compulsive Behaviors, National Institute of Mental Health, Bethesda, MD, USA., Li G; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China., Li Y; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China., Alvarez VA; Section on Neurobiology of Compulsive Behaviors, National Institute of Mental Health, Bethesda, MD, USA., Averbeck BB; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, USA. averbeckbb@mail.nih.gov., Penzo MA; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA. mario.penzo@nih.gov.
Source: Nature communications [Nat Commun] 2026 Jun 04; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Macdonald+EE%22">Macdonald EE</searchLink>; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA. emma.macdonald@nih.gov.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Yu+K%22">Yu K</searchLink>; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Walker+RA%22">Walker RA</searchLink>; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Authement+ME%22">Authement ME</searchLink>; Section on Neurobiology of Compulsive Behaviors, National Institute of Mental Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Leng+Y%22">Leng Y</searchLink>; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Goldbach+HC%22">Goldbach HC</searchLink>; Section on Neurobiology of Compulsive Behaviors, National Institute of Mental Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Alvarez+VA%22">Alvarez VA</searchLink>; Section on Neurobiology of Compulsive Behaviors, National Institute of Mental Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Averbeck+BB%22">Averbeck BB</searchLink>; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, USA. averbeckbb@mail.nih.gov.<br /><searchLink fieldCode="AU" term="%22Penzo+MA%22">Penzo MA</searchLink>; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health, Bethesda, MD, USA. mario.penzo@nih.gov.
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