BCL-2 and MCL1 co-inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A-rearranged acute lymphoblastic leukaemia.
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| Title: | BCL-2 and MCL1 co-inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A-rearranged acute lymphoblastic leukaemia. |
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| Authors: | Karsa M; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Karsa A; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia., Spurling D; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia., Xiao L; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Ronca E; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia., Bongers A; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia., Gao W; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Gifford AJ; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.; Anatomical Pathology, NSW Health Pathology, Prince of Wales Hospital, Randwick, New South Wales, Australia., El-Ayoubi A; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia., Cheung LC; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia, Perth, Western Australia, Australia.; Curtin Medical School, Curtin University, Perth, Western Australia, Australia.; Curtin Medical Research Institute, Curtin University, Perth, Western Australia, Australia., Kotecha RS; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia, Perth, Western Australia, Australia.; Curtin Medical School, Curtin University, Perth, Western Australia, Australia.; Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Western Australia, Australia.; Medical School, University of Western Australia, Perth, Western Australia, Australia., Lock RB; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Teh CE; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Lessene G; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia., Norris MD; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Wei A; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Haber M; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Henderson MJ; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Moujalled DM; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Somers K; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia. |
| Source: | British journal of haematology [Br J Haematol] 2026 Jun 05. Date of Electronic Publication: 2026 Jun 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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