HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition.
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| Title: | HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition. |
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| Authors: | Myers A; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America., Chandravanshi M; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America., Whitmore LS; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.; Washington National Biomedical Research Center, University of Washington, Seattle, Washington, United States of America., Kohrn BF; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America., Negash A; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America., Nguyen DN; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America., Ralli-Jain P; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America., Cruickshank K; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America., Upadhyay AA; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Charles T; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America., Edwards CT; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Hunter E; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Amara RR; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America., Korzeniowski MK; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America., Niu L; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America., Pozharski E; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America.; Institute for Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America., Tolbert WD; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America., Bosinger SE; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Kennedy SR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America., Pazgier M; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America., Derdeyn CA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.; Washington National Biomedical Research Center, University of Washington, Seattle, Washington, United States of America. |
| Source: | PLoS pathogens [PLoS Pathog] 2026 Jun 05; Vol. 22 (6), pp. e1014268. Date of Electronic Publication: 2026 Jun 05 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1553-7374 |
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| DOI: | 10.1371/journal.ppat.1014268 |
