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HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition.

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Title: HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition.
Authors: Myers A; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America., Chandravanshi M; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America., Whitmore LS; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.; Washington National Biomedical Research Center, University of Washington, Seattle, Washington, United States of America., Kohrn BF; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America., Negash A; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America., Nguyen DN; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America., Ralli-Jain P; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America., Cruickshank K; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America., Upadhyay AA; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Charles T; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America., Edwards CT; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Hunter E; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Amara RR; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America., Korzeniowski MK; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America., Niu L; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America., Pozharski E; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America.; Institute for Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America., Tolbert WD; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America., Bosinger SE; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Kennedy SR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America., Pazgier M; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America., Derdeyn CA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.; Washington National Biomedical Research Center, University of Washington, Seattle, Washington, United States of America.
Source: PLoS pathogens [PLoS Pathog] 2026 Jun 05; Vol. 22 (6), pp. e1014268. Date of Electronic Publication: 2026 Jun 05 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
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  Data: HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Myers+A%22">Myers A</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Chandravanshi+M%22">Chandravanshi M</searchLink>; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Whitmore+LS%22">Whitmore LS</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.; Washington National Biomedical Research Center, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Kohrn+BF%22">Kohrn BF</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Negash+A%22">Negash A</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Nguyen+DN%22">Nguyen DN</searchLink>; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Ralli-Jain+P%22">Ralli-Jain P</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Cruickshank+K%22">Cruickshank K</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Upadhyay+AA%22">Upadhyay AA</searchLink>; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Charles+T%22">Charles T</searchLink>; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Edwards+CT%22">Edwards CT</searchLink>; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Hunter+E%22">Hunter E</searchLink>; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Amara+RR%22">Amara RR</searchLink>; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Korzeniowski+MK%22">Korzeniowski MK</searchLink>; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Niu+L%22">Niu L</searchLink>; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Pozharski+E%22">Pozharski E</searchLink>; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America.; Institute for Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Tolbert+WD%22">Tolbert WD</searchLink>; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Bosinger+SE%22">Bosinger SE</searchLink>; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Kennedy+SR%22">Kennedy SR</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Pazgier+M%22">Pazgier M</searchLink>; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Derdeyn+CA%22">Derdeyn CA</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.; Washington National Biomedical Research Center, University of Washington, Seattle, Washington, United States of America.
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