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Structural and functional mapping of protective human monoclonal antibodies against enterovirus A71.

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Title: Structural and functional mapping of protective human monoclonal antibodies against enterovirus A71.
Authors: Zhou D; College of Life Sciences, Zhejiang University, Hangzhou, China.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kotecha A; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; St. Jude Children's Research Hospital, Inspiration 4 Advanced Research Center, 262 Danny Thomas Place, Memphis, TN, USA., Kelly JT; The Pirbright Institute, Woking, Surrey, UK., Huang PN; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Division of Pediatric Infectious Diseases, Department of Pediatrics, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan., Chen YY; Graduate Institute of Immunology and Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan., Walter TS; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Duyvesteyn HME; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Owens RJ; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; The Rosalind Franklin Institute, Harwell Campus, Didcot, UK., Ho SY; Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan., Lin TY; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Fry EE; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ren J; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Huang KA; Graduate Institute of Immunology and Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.; Genomics Research Center, Academia Sinica, Taipei, Taiwan., Stuart DI; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Source: Science advances [Sci Adv] 2026 Jun 05; Vol. 12 (23), pp. eaee8217. Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhou+D%22">Zhou D</searchLink>; College of Life Sciences, Zhejiang University, Hangzhou, China.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kotecha+A%22">Kotecha A</searchLink>; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; St. Jude Children's Research Hospital, Inspiration 4 Advanced Research Center, 262 Danny Thomas Place, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Kelly+JT%22">Kelly JT</searchLink>; The Pirbright Institute, Woking, Surrey, UK.<br /><searchLink fieldCode="AU" term="%22Huang+PN%22">Huang PN</searchLink>; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Division of Pediatric Infectious Diseases, Department of Pediatrics, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YY%22">Chen YY</searchLink>; Graduate Institute of Immunology and Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Walter+TS%22">Walter TS</searchLink>; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Duyvesteyn+HME%22">Duyvesteyn HME</searchLink>; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Owens+RJ%22">Owens RJ</searchLink>; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; The Rosalind Franklin Institute, Harwell Campus, Didcot, UK.<br /><searchLink fieldCode="AU" term="%22Ho+SY%22">Ho SY</searchLink>; Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+TY%22">Lin TY</searchLink>; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fry+EE%22">Fry EE</searchLink>; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ren+J%22">Ren J</searchLink>; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Huang+KA%22">Huang KA</searchLink>; Graduate Institute of Immunology and Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.; Genomics Research Center, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Stuart+DI%22">Stuart DI</searchLink>; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
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              Text: 2026 Jun 05
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