Alpha‑lipoic acid-loaded chitosan nanoparticles ameliorate streptozotocin‑induced diabetic liver injury via Nrf2/HO‑1 activation and TLR4/NF‑κB and JAK2/STAT1 inhibition.
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| Title: | Alpha‑lipoic acid-loaded chitosan nanoparticles ameliorate streptozotocin‑induced diabetic liver injury via Nrf2/HO‑1 activation and TLR4/NF‑κB and JAK2/STAT1 inhibition. |
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| Authors: | Abdalla HA; Department of Basic Medical Sciences, College of Medicine, Taibah University, Madinah, Saudi Arabia.; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt., Elmorsy EM; Center for Health Research, Northern Border University, Arar, 73213, Saudi Arabia., Jawad NMM; Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia., Hosny N; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt., Shams AS; Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt., Ayaz RA; King Fahad Armed Forces Hospital, Medical Laboratory Technology-MsC Hematology, Jeddah, Saudi Arabia., Fawzy MS; Center for Health Research, Northern Border University, Arar, 73213, Saudi Arabia. manal.darwish@nbu.edu.sa., Elshopakey GE; Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt. |
| Source: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jun 06. Date of Electronic Publication: 2026 Jun 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42249096 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Alpha‑lipoic acid-loaded chitosan nanoparticles ameliorate streptozotocin‑induced diabetic liver injury via Nrf2/HO‑1 activation and TLR4/NF‑κB and JAK2/STAT1 inhibition. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Abdalla+HA%22">Abdalla HA</searchLink>; Department of Basic Medical Sciences, College of Medicine, Taibah University, Madinah, Saudi Arabia.; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.<br /><searchLink fieldCode="AU" term="%22Elmorsy+EM%22">Elmorsy EM</searchLink>; Center for Health Research, Northern Border University, Arar, 73213, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Jawad+NMM%22">Jawad NMM</searchLink>; Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Hosny+N%22">Hosny N</searchLink>; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.<br /><searchLink fieldCode="AU" term="%22Shams+AS%22">Shams AS</searchLink>; Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.<br /><searchLink fieldCode="AU" term="%22Ayaz+RA%22">Ayaz RA</searchLink>; King Fahad Armed Forces Hospital, Medical Laboratory Technology-MsC Hematology, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Fawzy+MS%22">Fawzy MS</searchLink>; Center for Health Research, Northern Border University, Arar, 73213, Saudi Arabia. manal.darwish@nbu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Elshopakey+GE%22">Elshopakey GE</searchLink>; Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220326264%22">Naunyn-Schmiedeberg's archives of pharmacology</searchLink> [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jun 06. <i>Date of Electronic Publication: </i>2026 Jun 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0326264 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1912 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200281298%22">00281298 </searchLink><i>NLM ISO Abbreviation: </i>Naunyn Schmiedebergs Arch Pharmacol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42249096 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00210-026-05521-4 Languages: – Code: eng Text: English Titles: – TitleFull: Alpha‑lipoic acid-loaded chitosan nanoparticles ameliorate streptozotocin‑induced diabetic liver injury via Nrf2/HO‑1 activation and TLR4/NF‑κB and JAK2/STAT1 inhibition. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Abdalla HA – PersonEntity: Name: NameFull: Elmorsy EM – PersonEntity: Name: NameFull: Jawad NMM – PersonEntity: Name: NameFull: Hosny N – PersonEntity: Name: NameFull: Shams AS – PersonEntity: Name: NameFull: Ayaz RA – PersonEntity: Name: NameFull: Fawzy MS – PersonEntity: Name: NameFull: Elshopakey GE IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 06 Text: 2026 Jun 06 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1432-1912 Titles: – TitleFull: Naunyn-Schmiedeberg's archives of pharmacology Type: main |
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