Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.

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Title: Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.
Authors: Rodriguez GA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA., Aoun A; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA; Burke Neurological Institute, White Plains, NY 10605, USA; Center for Neural Science, New York University, New York, NY 10003, USA., Rothenberg EF; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA., Shetler CO; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA., Posani L; Department of Neuroscience, Columbia University Irving Medical Center, New York, NY 10027, USA; Center for Theoretical Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Vajram SV; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA., Tedesco T; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA., Sharma A; Burke Neurological Institute, White Plains, NY 10605, USA., Fusi S; Department of Neuroscience, Columbia University Irving Medical Center, New York, NY 10027, USA; Center for Theoretical Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Kavli Institute for Brain Science, Columbia University, New York, NY 10027, USA., Hussaini SA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA; Burke Neurological Institute, White Plains, NY 10605, USA; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: syh7006@med.cornell.edu.
Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117505. Date of Electronic Publication: 2026 Jun 06.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2211-1247
DOI:10.1016/j.celrep.2026.117505