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Intraindividual cognitive variability predicts amyloid beta, tau PET, and dementia conversion in Down syndrome: a potential marker of cognitive resilience.

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Title: Intraindividual cognitive variability predicts amyloid beta, tau PET, and dementia conversion in Down syndrome: a potential marker of cognitive resilience.
Authors: Fonseca LM; The Krieger Klein Alzheimer's Research Center, Rutgers Health, New Brunswick, New Jersey, USA.; Programa Terceira Idade (PROTER, Old Age Research Group), Department and Institute of Psychiatry, University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil., Lila E; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Shojaie A; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Chhatwal J; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA., Forlenza O; Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil., Beeri MS; The Krieger Klein Alzheimer's Research Center, Rutgers Health, New Brunswick, New Jersey, USA., Krinsky-McHale S; New York State Institute for Basic Research in Developmental Disabilities, New York, New York, USA., Cohen AD; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Christian BT; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Head E; Department of Pathology and Laboratory Medicine, University of California, Irvine, California, USA., Mapstone M; Department of Neurology, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA., Handen B; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Ances BM; Department of Neurology, Washington University in St Louis, St Louis, Missouri, USA., Grabowski T; Departments of Radiology and Neurology, University of Washington, Seattle, Washington, USA., Chaytor NS; Department of Community and Behavioral Health, Elson S Floyd College of Medicine, Washington State University, Spokane, Washington, USA., Zaman S; Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK.; Cambridgeshire & Peterborough NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Corporate Authors: Alzheimer's Biomarkers Consortium‐ Down Syndrome (ABC‐DS) Investigators
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jun; Vol. 22 (6), pp. e71537.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intraindividual cognitive variability predicts amyloid beta, tau PET, and dementia conversion in Down syndrome: a potential marker of cognitive resilience.
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  Data: <searchLink fieldCode="AU" term="%22Fonseca+LM%22">Fonseca LM</searchLink>; The Krieger Klein Alzheimer's Research Center, Rutgers Health, New Brunswick, New Jersey, USA.; Programa Terceira Idade (PROTER, Old Age Research Group), Department and Institute of Psychiatry, University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Lila+E%22">Lila E</searchLink>; Department of Biostatistics, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Shojaie+A%22">Shojaie A</searchLink>; Department of Biostatistics, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Chhatwal+J%22">Chhatwal J</searchLink>; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Forlenza+O%22">Forlenza O</searchLink>; Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Beeri+MS%22">Beeri MS</searchLink>; The Krieger Klein Alzheimer's Research Center, Rutgers Health, New Brunswick, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Krinsky-McHale+S%22">Krinsky-McHale S</searchLink>; New York State Institute for Basic Research in Developmental Disabilities, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+AD%22">Cohen AD</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Christian+BT%22">Christian BT</searchLink>; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Head+E%22">Head E</searchLink>; Department of Pathology and Laboratory Medicine, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Mapstone+M%22">Mapstone M</searchLink>; Department of Neurology, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Handen+B%22">Handen B</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Ances+BM%22">Ances BM</searchLink>; Department of Neurology, Washington University in St Louis, St Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Grabowski+T%22">Grabowski T</searchLink>; Departments of Radiology and Neurology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Chaytor+NS%22">Chaytor NS</searchLink>; Department of Community and Behavioral Health, Elson S Floyd College of Medicine, Washington State University, Spokane, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Zaman+S%22">Zaman S</searchLink>; Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK.; Cambridgeshire & Peterborough NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 Jun; Vol. 22 (6), pp. e71537.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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