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Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.

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Title: Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.
Authors: Farombi T; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Chief Tony Anineh Geriatric Center, University College Hospital, Ibadan, Oyo State, Nigeria., Azzi T; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands., Legaz A; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, California, USA.; Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Victoria, Buenos Aires, Argentina.; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Peñalolén, Santiago, Chile., Aguillón D; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia., Avila-Funes JA; Dirección de Enseñanza, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Tlalpan, México., Behrens MI; Centro de Investigación Clínica Avanzada (CICA), Hospital Clínico Universidad de Chile, Santiago, Chile.; Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile, Santiago, Chile.; Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Departamento de Neurología y Psiquiatría, Clínica Alemana - Universidad del Desarrollo, Santiago, Chile., Bruno M; Instituto Ciencias Biomedicas (ICBM), Facultad Ciencias Medicas, Universidad Catolica de Cuyo, San Juan, Argentina.; National Council on Scientific and Technical Research (CONICET), Buenos Aires, Argentina., Cardona JF; Facultad de Psicología, Universidad del Valle, Cali, Valle del Cauca, Colombia., Custodio N; Unidad de Investigación de Deterioro Cognitivo y Prevención de Demencia, Instituto Peruano de Neurociencias, Lince, Peru.; Unidad de Investigación y Docencia, Equilibria, Santiago de Surco, Lima, Perú., Delgado C; Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Departamento de Neurología y Neurocirugía, Hospital Clínico, Unidad de Cerebro Saludable, Universidad de Chile, Santiago, Chile., Pina-Escudero S; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, California, USA.; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Galofre MDPG; Fundación Universidad del Norte, Barranquilla, Atlántico, Colombia., Maito M; Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Victoria, Buenos Aires, Argentina.; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Peñalolén, Santiago, Chile., Magrath-Guimet N; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, California, USA.; Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría, FLENI, Buenos Aires, Argentina., Miller JB; Department of Neurology, University of Washington, Seattle, Washington, USA., Matallana D; Departamento de Salud Mental, Hospital Universitario Fundación Santa Fe, Bogotá, Colombia.; Centro de Memoria y Cognición, Hospital Universitario San Ignacio, Bogotá, Colombia., de Oliveira MO; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, California, USA.; Cognitive Neurology and Behavioral Unit (GNCC), University of São Paulo, São Paulo, Brazil., Rocatti G; Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Victoria, Buenos Aires, Argentina., Resende EPF; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, California, USA.; Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Slachevsky A; Departamento de Neurología y Psiquiatría, Clínica Alemana - Universidad del Desarrollo, Santiago, Chile.; Centro Gerociencias, Salud Mental y Metabolismo (GERO), Santiago, Chile.; Laboratorio de Neuropsicología y Neurociencias Clínicas (LANNEC) Programa de Fisiopatología-ICBM, Departamento de Ciencias Neurológicas Oriente y Neurociencias, Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Centro de Memoria y Neuropsiquiatría (CMYN), Servicio de Neurología, Hospital del Salvador y Facultad de Medicina, Universidad de Chile, Santiago, Chile., Takada L; Cognitive Neurology and Behavioral Unit (GNCC), University of São Paulo, São Paulo, Brazil., Wen O; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Peñalolén, Santiago, Chile.; Trinity College Dublin, Dublin, Ireland., Zapata-Restrepo LM; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, California, USA.; Fundación Valle del Lili, Cali ,Valle del Cauca, Colombia.; Universidad Icesi, Cali, Valle del Cauca, Colombia., Lawlor B; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland., Yaffe K; UCSF School of Medicine, University of California, San Francisco, San Francisco, California, USA.; Center for Population Brain Health, University of California, San Francisco, San Francisco, California, USA., Hu K; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA., Miller B; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, California, USA.; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Possin K; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, California, USA.; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Yokoyama JS; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA., Fittipaldi S; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Victoria, Buenos Aires, Argentina., García AM; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, California, USA.; Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Victoria, Buenos Aires, Argentina.; Departamento de Lingüística y Literatura, Facultad de Humanidades, Universidad de Santiago de Chile, Santiago, Chile., Larzabal HH; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Peñalolén, Santiago, Chile., Santamaria-Garcia H; Centro de Memoria y Cognición Intellectus, Hospital Universitario San Ignacio, Bogotá, Colombia.; PhD Program of Neuroscience, Pontificia Universidad Javeriana, Bogotá, Colombia.; Laboratory of Cognition, Neurosciences, and Context. Department of Psychiatry, Universidad Javeriana, Bogotá, Colombia., Tagliazzuchi E; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Peñalolén, Santiago, Chile.; Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, CONICET, Buenos Aires, Argentina., Duran-Aniotz C; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Peñalolén, Santiago, Chile., Ibanez A; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Victoria, Buenos Aires, Argentina.; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Peñalolén, Santiago, Chile.; Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Türkiye.; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain., Migeot J; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Peñalolén, Santiago, Chile.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jun; Vol. 22 (6), pp. e71534.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1552-5279
DOI:10.1002/alz.71534