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Endurance exercise elicits temporal and sexual dimorphic multi-omics remodeling of liver metabolism revealed by MoTrPAC.

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Title: Endurance exercise elicits temporal and sexual dimorphic multi-omics remodeling of liver metabolism revealed by MoTrPAC.
Authors: Kelty TJ; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA., Franczak E; Departments of Cell Biology and Physiology and Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA; Kansas Center for Metabolism and Obesity Research and KU Diabetes Institute, University of Kansas Medical Center, Kansas City, KS, USA., Gay NR; Department of Genetics, Stanford University, Stanford, CA, USA., Many GM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Sagendorf TJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Sanford JA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Hou Z; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Gaul DA; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA., Fernández FM; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA., Rekowski M; Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, USA; Mass Spectrometry and Proteomics Core Facility, University of Kansas Medical Center, Kansas City, KS, USA., Burant CF; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Hevener AL; Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA, USA., Adkins JN; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Bodine S; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Lindholm ME; Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA., Ortlund EA; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Schenk S; Department of Orthopedic Surgery, School of Medicine, University of California, San Diego, La Jolla, CA, USA., Thyfault JP; Departments of Cell Biology and Physiology and Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA; Kansas Center for Metabolism and Obesity Research and KU Diabetes Institute, University of Kansas Medical Center, Kansas City, KS, USA; Research Service, Kansas City VA Medical Center, Kansas City, MO, USA. Electronic address: jthyfault@kumc.edu., Rector RS; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA; Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, MO, USA; Research Service, Harry S. Truman Memorial VA Medical Center, Columbia, MO, USA. Electronic address: rectors@health.missouri.edu.
Corporate Authors: MoTrPAC study group
Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117416. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Kelty+TJ%22">Kelty TJ</searchLink>; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA.<br /><searchLink fieldCode="AU" term="%22Franczak+E%22">Franczak E</searchLink>; Departments of Cell Biology and Physiology and Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA; Kansas Center for Metabolism and Obesity Research and KU Diabetes Institute, University of Kansas Medical Center, Kansas City, KS, USA.<br /><searchLink fieldCode="AU" term="%22Gay+NR%22">Gay NR</searchLink>; Department of Genetics, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Many+GM%22">Many GM</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Sagendorf+TJ%22">Sagendorf TJ</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Sanford+JA%22">Sanford JA</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hou+Z%22">Hou Z</searchLink>; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Gaul+DA%22">Gaul DA</searchLink>; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Fernández+FM%22">Fernández FM</searchLink>; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Rekowski+M%22">Rekowski M</searchLink>; Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, USA; Mass Spectrometry and Proteomics Core Facility, University of Kansas Medical Center, Kansas City, KS, USA.<br /><searchLink fieldCode="AU" term="%22Burant+CF%22">Burant CF</searchLink>; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Hevener+AL%22">Hevener AL</searchLink>; Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Adkins+JN%22">Adkins JN</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bodine+S%22">Bodine S</searchLink>; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Lindholm+ME%22">Lindholm ME</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ortlund+EA%22">Ortlund EA</searchLink>; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Schenk+S%22">Schenk S</searchLink>; Department of Orthopedic Surgery, School of Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Thyfault+JP%22">Thyfault JP</searchLink>; Departments of Cell Biology and Physiology and Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA; Kansas Center for Metabolism and Obesity Research and KU Diabetes Institute, University of Kansas Medical Center, Kansas City, KS, USA; Research Service, Kansas City VA Medical Center, Kansas City, MO, USA. Electronic address: jthyfault@kumc.edu.<br /><searchLink fieldCode="AU" term="%22Rector+RS%22">Rector RS</searchLink>; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA; Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, MO, USA; Research Service, Harry S. Truman Memorial VA Medical Center, Columbia, MO, USA. Electronic address: rectors@health.missouri.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117416. <i>Date of Electronic Publication: </i>2026 Jun 08.
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