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Prognostic impact of variant allele frequency in intensively treated patients with NPM1-mutated AML: a PETHEMA study.

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Title: Prognostic impact of variant allele frequency in intensively treated patients with NPM1-mutated AML: a PETHEMA study.
Authors: Gil JV; Accredited Research Group on Hematology, Instituto de Investigación Sanitaria la Fe, 46026 Valencia, Spain, Valencia, Spain., Sargas C; Instituto de Investigación Sanitaria La Fe, Valencia, Spain., Ayala R; HOSPITAL 12 DE OCTUBRE, MADRID, Spain., Gutierrez NC; Hospital Universitario de Salamanca. IBSAL. Centro de Investigación del Cáncer, Salamanca, Spain., Pérez-Simón JA; Hospital Universitario Virgen del Rocio, Sevilla, Spain., Gómez-Casares MT; Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas de Gran Canarias, Spain., Larrayoz MJ; Navarra University Clinic, PAMPLONA, Spain., Prados de la Torre E; University of Cordoba (UCO), Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Hematology Unit, Reina Sofia University Hospital, Córdoba, Spain., Cano-Ferri I; Hospital Universitari i Politècnic La Fe, Valencia, Spain., Navarro I; Hematology Department, Hospital Universitari i Politècnic, La Fe, Valencia, València, Spain., Gil C; Hospital Alicante, alicante, Spain., Bernal Del Castillo T; Hospital Central de Asturias, ISPA, IUOPAs, Oviedo, Spain., Rodríguez-Arbolí E; Department of Hematology, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBiS/CSIC), University of Seville, Seville, Spain., Pérez Santaolalla E; Hospital Universitario de Donostia, Donostia, Spain., Colmenares R; Hospital Universitario 12 De Octubre, Madrid, Spain., Tormo M; Hospital Clinico Universitary. INCLIVA Research Institute, Valencia 46010, Spain., Bergua Burgues JM; Hospital San Pedro de Alcántara. Cáceres, Caceres, Spain., Amigo ML; Hospital Morales Meseguer, Murcia, Spain., Rodríguez-Medina C; Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas De Gran Canaria, Spain., Serrano J; University Hospital Reina Sofia. IMIBIC. UCO, Cordoba, Spain., Oliva A; Hospital Virgen de la Candelaria, Tenerife, Spain., Alonso-Domínguez JM; Princess Margaret Cancer Centre, Toronto, Ma, Canada., Noriega V; Complejo Hospitalario Universitario A Coruña, A Coruña, Spain., Algarra JL; Hospital General de Albacete, Albacete, Spain., Olave MT; Hospital Clínico Lozano Blesa. Zaragoza, ZARAGOZA, Spain., García Perez MJ; Hospital Universitario Torrecárdenas, Almeria, Spain., Couto MDC; University Hospital Virgen de Valme, Sevilla, Spain., Almela-Gallego A; Leon University Hospital, Leon, Spain., García-Fortes M; Hospital Universitario Virgen de la Victoria, Málaga, Spain., Madrigal-Toscano DD; Virgen Macarena University Hospital, Seville, Spain., Hermosín L; Servicio Hematología, Hospital de Jerez, Jerez de la Frontera, Jerez de la Frontera, Cadiz, Spain., Colorado M; Hospital Universitario Marqués de Valdecilla, Santander, Spain., García-Boyero R; Hospital General Universitario de Castellón, Castellón, Spain., Ibañez-Alis F; Valencia General Hospital, Valencia, Spain., Solé-Rodríguez M; Department of Haematology of Hospital Juan Ramón Jiménez, Huelva, Huelva, Spain., Martinez Chamorro C; Hospital Universitario Quironsalud Madrid and Universidad Europea de Madrid, Pozuelo de Alarcon, Spain., Mateos MC; Complejo Hospitalario de Navarra, Pamplona, Spain., García Garay MDC; Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain., Solana-Altabella A; Hospital Universitari i Politècnic La Fe; Dep. of Pharmacy, University of Valencia, Valencia, Spain., Martín-Herreros B; Instituto de Investigación Sanitaria La Fe, València, Spain., Martínez-López J; Department of Hematology, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, Centro Nacional de Investigaciones Oncológicas, Centro de Investigación Biomédic, Madrid, Spain., Chillon MC; Hospital Universitario de Salamanca, IBSAL, CIBER-ONC number CB16/12/00233 y Centro de Investigacion del Cancer de Salamanca-IBMCC (USAL-CSIC), Salamanca, Salamanca, Spain., Soria E; Virgen del Rocio University Hospital, Institute of Biomedicine of Seville (IBIS/CSIC), University of Seville, Seville, Spain., Bilbao-Sieyro C; Hospital Universitario de Gran Canaria Dr. Negrín, Instituto de Investigación Sanitaria de Canarias (IISC), Las Palmas De Gran Canaria, Spain., Calasanz MJJ; UNIVERSITY OF NAVARRA, Pamplona, Spain., Sánchez-García J; Hospital Universitario Reina Sofía, Córdoba, Spain., Barragan E; Hospital La Fe, Valencia, Spain., Montesinos P; Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Source: Blood [Blood] 2026 Jun 08. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Prognostic impact of variant allele frequency in intensively treated patients with NPM1-mutated AML: a PETHEMA study.
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  Data: <searchLink fieldCode="AU" term="%22Gil+JV%22">Gil JV</searchLink>; Accredited Research Group on Hematology, Instituto de Investigación Sanitaria la Fe, 46026 Valencia, Spain, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Sargas+C%22">Sargas C</searchLink>; Instituto de Investigación Sanitaria La Fe, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Ayala+R%22">Ayala R</searchLink>; HOSPITAL 12 DE OCTUBRE, MADRID, Spain.<br /><searchLink fieldCode="AU" term="%22Gutierrez+NC%22">Gutierrez NC</searchLink>; Hospital Universitario de Salamanca. IBSAL. Centro de Investigación del Cáncer, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez-Simón+JA%22">Pérez-Simón JA</searchLink>; Hospital Universitario Virgen del Rocio, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Gómez-Casares+MT%22">Gómez-Casares MT</searchLink>; Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas de Gran Canarias, Spain.<br /><searchLink fieldCode="AU" term="%22Larrayoz+MJ%22">Larrayoz MJ</searchLink>; Navarra University Clinic, PAMPLONA, Spain.<br /><searchLink fieldCode="AU" term="%22Prados+de+la+Torre+E%22">Prados de la Torre E</searchLink>; University of Cordoba (UCO), Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Hematology Unit, Reina Sofia University Hospital, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22Cano-Ferri+I%22">Cano-Ferri I</searchLink>; Hospital Universitari i Politècnic La Fe, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Navarro+I%22">Navarro I</searchLink>; Hematology Department, Hospital Universitari i Politècnic, La Fe, Valencia, València, Spain.<br /><searchLink fieldCode="AU" term="%22Gil+C%22">Gil C</searchLink>; Hospital Alicante, alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Bernal+Del+Castillo+T%22">Bernal Del Castillo T</searchLink>; Hospital Central de Asturias, ISPA, IUOPAs, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Arbolí+E%22">Rodríguez-Arbolí E</searchLink>; Department of Hematology, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBiS/CSIC), University of Seville, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez+Santaolalla+E%22">Pérez Santaolalla E</searchLink>; Hospital Universitario de Donostia, Donostia, Spain.<br /><searchLink fieldCode="AU" term="%22Colmenares+R%22">Colmenares R</searchLink>; Hospital Universitario 12 De Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Tormo+M%22">Tormo M</searchLink>; Hospital Clinico Universitary. 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