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Evaluation of the effectiveness of artemether-lumefantrine and artesunate-pyronaridine each combined with single low-dose primaquine in adults with Plasmodium falciparum infection in Ethiopia: a phase 2/3, observer-masked, randomised, parallel-group trial.

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Title: Evaluation of the effectiveness of artemether-lumefantrine and artesunate-pyronaridine each combined with single low-dose primaquine in adults with Plasmodium falciparum infection in Ethiopia: a phase 2/3, observer-masked, randomised, parallel-group trial.
Authors: Bezabih MK; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands., Misganaw T; Department of Medical Laboratory Science, Bahir Dar University, Bahir Dar, Ethiopia., Ejigu LA; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Rosillo S; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Teka H; US President's Malaria Initiative, US Agency for International Development (USAID), Addis Ababa, Ethiopia., Alemayehu DH; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Adnew B; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Hailegiorgis B; US President's Malaria Initiative Malaria Laboratory Diagnosis and Treatment Activity, International Center for AIDS Care and Treatment Programs at Columbia University, Addis Ababa, Ethiopia., Girma S; US President's Malaria Initiative, US Agency for International Development (USAID), Addis Ababa, Ethiopia., Tadesse M; US President's Malaria Initiative Malaria Laboratory Diagnosis and Treatment Activity, International Center for AIDS Care and Treatment Programs at Columbia University, Addis Ababa, Ethiopia., Kassa FA; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Gebremichael M; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Tefera DA; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Chali W; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands., Behaksera SW; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Alemayehu L; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Deressa JD; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Abdo M; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Habtamu G; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Gizat A; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Yalew WG; Department of Medical Laboratory Science, Bahir Dar University, Bahir Dar, Ethiopia., Jember TH; Department of Medical Laboratory Science, Bahir Dar University, Bahir Dar, Ethiopia., Bitew M; Bio and Emerging Technology Institute, Addis Ababa, Ethiopia., Mumba P; US President's Malaria Initiative, US Agency for International Development (USAID), Addis Ababa, Ethiopia., Plucinski MM; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Souza S; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Patel DS; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Talundzic E; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Taffese HS; Ministry of Health, Addis Ababa, Ethiopia., Geleta KE; Ministry of Health, Addis Ababa, Ethiopia., Mehari D; Ministry of Health, Addis Ababa, Ethiopia., Bayissa GA; Ministry of Health, Addis Ababa, Ethiopia., Bousema T; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands., Tongren JE; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Hwang J; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Tadesse FG; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK. Electronic address: fitsum.girma@ahri.gov.et.
Source: The Lancet. Microbe [Lancet Microbe] 2026 Dec 18, pp. 101344. Date of Electronic Publication: 2026 Dec 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE
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  Data: Evaluation of the effectiveness of artemether-lumefantrine and artesunate-pyronaridine each combined with single low-dose primaquine in adults with Plasmodium falciparum infection in Ethiopia: a phase 2/3, observer-masked, randomised, parallel-group trial.
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  Data: <searchLink fieldCode="AU" term="%22Bezabih+MK%22">Bezabih MK</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Misganaw+T%22">Misganaw T</searchLink>; Department of Medical Laboratory Science, Bahir Dar University, Bahir Dar, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Ejigu+LA%22">Ejigu LA</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Rosillo+S%22">Rosillo S</searchLink>; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Teka+H%22">Teka H</searchLink>; US President's Malaria Initiative, US Agency for International Development (USAID), Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Alemayehu+DH%22">Alemayehu DH</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Adnew+B%22">Adnew B</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Hailegiorgis+B%22">Hailegiorgis B</searchLink>; US President's Malaria Initiative Malaria Laboratory Diagnosis and Treatment Activity, International Center for AIDS Care and Treatment Programs at Columbia University, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Girma+S%22">Girma S</searchLink>; US President's Malaria Initiative, US Agency for International Development (USAID), Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Tadesse+M%22">Tadesse M</searchLink>; US President's Malaria Initiative Malaria Laboratory Diagnosis and Treatment Activity, International Center for AIDS Care and Treatment Programs at Columbia University, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Kassa+FA%22">Kassa FA</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Gebremichael+M%22">Gebremichael M</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Tefera+DA%22">Tefera DA</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Chali+W%22">Chali W</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Behaksera+SW%22">Behaksera SW</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Alemayehu+L%22">Alemayehu L</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Deressa+JD%22">Deressa JD</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Abdo+M%22">Abdo M</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Habtamu+G%22">Habtamu G</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Gizat+A%22">Gizat A</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Yalew+WG%22">Yalew WG</searchLink>; Department of Medical Laboratory Science, Bahir Dar University, Bahir Dar, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Jember+TH%22">Jember TH</searchLink>; Department of Medical Laboratory Science, Bahir Dar University, Bahir Dar, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Bitew+M%22">Bitew M</searchLink>; Bio and Emerging Technology Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Mumba+P%22">Mumba P</searchLink>; US President's Malaria Initiative, US Agency for International Development (USAID), Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Plucinski+MM%22">Plucinski MM</searchLink>; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Souza+S%22">Souza S</searchLink>; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+DS%22">Patel DS</searchLink>; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Talundzic+E%22">Talundzic E</searchLink>; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Taffese+HS%22">Taffese HS</searchLink>; Ministry of Health, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Geleta+KE%22">Geleta KE</searchLink>; Ministry of Health, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Mehari+D%22">Mehari D</searchLink>; Ministry of Health, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Bayissa+GA%22">Bayissa GA</searchLink>; Ministry of Health, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Bousema+T%22">Bousema T</searchLink>; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Tongren+JE%22">Tongren JE</searchLink>; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Hwang+J%22">Hwang J</searchLink>; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Tadesse+FG%22">Tadesse FG</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK. Electronic address: fitsum.girma@ahri.gov.et.
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  Data: <searchLink fieldCode="JN" term="%22101769019%22">The Lancet. Microbe</searchLink> [Lancet Microbe] 2026 Dec 18, pp. 101344. <i>Date of Electronic Publication: </i>2026 Dec 18.
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