Targeting cancer-specific mutations with RNA-triggered chromatin shredding.

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Title: Targeting cancer-specific mutations with RNA-triggered chromatin shredding.
Authors: Zeng J; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA., Cheng Z; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; School of Biological Science, University of Manchester, Manchester, UK., Chen H; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Wang Z; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Thompson J; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Crosby KT; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA., Han H; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Singhal A; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Ngo W; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA., Xia C; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Rosas-Rivera D; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Zhang Z; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA., Kang MH; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Mao Y; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Diolaiti ME; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Lee GC; The Francis Crick Institute, London, UK., Diffley JFX; The Francis Crick Institute, London, UK., Song Y; The Francis Crick Institute, London, UK., Qiu L; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Krah NM; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA., Murthy N; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Jackson RN; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA., Liu Y; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Ashworth A; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Doudna JA; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA. doudna@berkeley.edu.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. doudna@berkeley.edu.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. doudna@berkeley.edu.; Li Ka Shing Center for Genomic Engineering, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.
Source: Nature [Nature] 2026 Aug; Vol. 656 (8126), pp. 199-206. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-026-10738-7