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Targeting cancer-specific mutations with RNA-triggered chromatin shredding.

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Title: Targeting cancer-specific mutations with RNA-triggered chromatin shredding.
Authors: Zeng J; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA., Cheng Z; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; School of Biological Science, University of Manchester, Manchester, UK., Chen H; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Wang Z; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Thompson J; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Crosby KT; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA., Han H; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Singhal A; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Ngo W; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA., Xia C; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Rosas-Rivera D; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Zhang Z; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA., Kang MH; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Mao Y; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Diolaiti ME; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Lee GC; The Francis Crick Institute, London, UK., Diffley JFX; The Francis Crick Institute, London, UK., Song Y; The Francis Crick Institute, London, UK., Qiu L; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Krah NM; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA., Murthy N; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Jackson RN; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA., Liu Y; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Ashworth A; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Doudna JA; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA. doudna@berkeley.edu.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. doudna@berkeley.edu.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. doudna@berkeley.edu.; Li Ka Shing Center for Genomic Engineering, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.
Source: Nature [Nature] 2026 Aug; Vol. 656 (8126), pp. 199-206. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Targeting cancer-specific mutations with RNA-triggered chromatin shredding.
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  Data: <searchLink fieldCode="AU" term="%22Zeng+J%22">Zeng J</searchLink>; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+Z%22">Cheng Z</searchLink>; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; School of Biological Science, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+J%22">Thompson J</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Crosby+KT%22">Crosby KT</searchLink>; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA.<br /><searchLink fieldCode="AU" term="%22Han+H%22">Han H</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Singhal+A%22">Singhal A</searchLink>; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ngo+W%22">Ngo W</searchLink>; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xia+C%22">Xia C</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rosas-Rivera+D%22">Rosas-Rivera D</searchLink>; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kang+MH%22">Kang MH</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mao+Y%22">Mao Y</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Diolaiti+ME%22">Diolaiti ME</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+GC%22">Lee GC</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Diffley+JFX%22">Diffley JFX</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Qiu+L%22">Qiu L</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Krah+NM%22">Krah NM</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Murthy+N%22">Murthy N</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+RN%22">Jackson RN</searchLink>; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Ashworth+A%22">Ashworth A</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Doudna+JA%22">Doudna JA</searchLink>; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA. doudna@berkeley.edu.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. doudna@berkeley.edu.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. doudna@berkeley.edu.; Li Ka Shing Center for Genomic Engineering, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.
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