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Caspase-8 silences cell death-independent constitutive immune activation driven by tonic TNF-α.

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Title: Caspase-8 silences cell death-independent constitutive immune activation driven by tonic TNF-α.
Authors: Lentini G; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy., Coppolino F; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy., Famà A; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy., De Gaetano GV; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy., Grasso F; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy., Fiore L; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy., Berbiglia A; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy., Carnevale S; Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy., Venza I; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Lien E; Division of Infectious Diseases and Immunology, Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.; Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Venza M; Department of Biomedical and Dental Sciences and Morphological and Functional Images, University of Messina, Messina, Italy., Jaillon S; Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.; Department of Molecular Medicine, Immunology and General Pathology Unit, University of Pavia, Pavia, Italy., Teti G; Scylla Biotech Srl, Messina, Italy. gioteti@mac.com., Beninati C; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy.; Scylla Biotech Srl, Messina, Italy.
Source: EMBO reports [EMBO Rep] 2026 Jul; Vol. 27 (14), pp. 4054-4078. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lentini+G%22">Lentini G</searchLink>; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Coppolino+F%22">Coppolino F</searchLink>; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Famà+A%22">Famà A</searchLink>; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22De+Gaetano+GV%22">De Gaetano GV</searchLink>; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Grasso+F%22">Grasso F</searchLink>; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Fiore+L%22">Fiore L</searchLink>; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Berbiglia+A%22">Berbiglia A</searchLink>; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Carnevale+S%22">Carnevale S</searchLink>; Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Venza+I%22">Venza I</searchLink>; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Lien+E%22">Lien E</searchLink>; Division of Infectious Diseases and Immunology, Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.; Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Venza+M%22">Venza M</searchLink>; Department of Biomedical and Dental Sciences and Morphological and Functional Images, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Jaillon+S%22">Jaillon S</searchLink>; Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.; Department of Molecular Medicine, Immunology and General Pathology Unit, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Teti+G%22">Teti G</searchLink>; Scylla Biotech Srl, Messina, Italy. gioteti@mac.com.<br /><searchLink fieldCode="AU" term="%22Beninati+C%22">Beninati C</searchLink>; Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, Italy.; Scylla Biotech Srl, Messina, Italy.
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