Guiding the Molnupiravir Tablet Formulation Using Physiologically Based Biopharmaceutics Modeling and Successfully Establishing Dissolution Safe Space.

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Title: Guiding the Molnupiravir Tablet Formulation Using Physiologically Based Biopharmaceutics Modeling and Successfully Establishing Dissolution Safe Space.
Authors: Morrow T; Development Sciences and Clinical Supply , MRL, Merck & Co., Inc., Rahway, NJ, 07065, USA., Jarvi N; Development Sciences and Clinical Supply , MRL, Merck & Co., Inc., Rahway, NJ, 07065, USA., Halota M; Development Sciences and Clinical Supply , MRL, Merck & Co., Inc., Rahway, NJ, 07065, USA., Sun C; Development Sciences and Clinical Supply , MRL, Merck & Co., Inc., Rahway, NJ, 07065, USA., Kafle P; Development Sciences and Clinical Supply , MRL, Merck & Co., Inc., Rahway, NJ, 07065, USA., King R; Development Sciences and Clinical Supply , MRL, Merck & Co., Inc., Rahway, NJ, 07065, USA., Okoh G; Development Sciences and Clinical Supply , MRL, Merck & Co., Inc., Rahway, NJ, 07065, USA., Patel S; Development Sciences and Clinical Supply , MRL, Merck & Co., Inc., Rahway, NJ, 07065, USA., Heimbach T; Development Sciences and Clinical Supply , MRL, Merck & Co., Inc., Rahway, NJ, 07065, USA. Tycho.Heimbach@Merck.com.
Source: The AAPS journal [AAPS J] 2026 Jun 08; Vol. 28 (4). Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1550-7416
DOI:10.1208/s12248-026-01249-4