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Safety and effectiveness of tocilizumab in systemic sclerosis: a multicentre French-Italian study.

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Title: Safety and effectiveness of tocilizumab in systemic sclerosis: a multicentre French-Italian study.
Authors: Buonsante G; IRCCS and INFLAGE San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.; Department of Rheumatology, Université Paris Cité, Cochin Institute, Paris, France., De Luca G; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases (UnIRAR), San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Marazzi E; SC Reumatologia, Università di Pavia, Pavia, Italy., Cacciapaglia F; Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, Università degli Studi di Bari Aldo Moro, Bari, Italy., Lazzaroni MG; Rheumatology and Clinical Immunology, ASST Spedali Civili di Brescia, Brescia, Italy., De Pinto M; Rheumatology, University of Modena and Reggio Emilia, Modena, Italy., Benfaremo D; Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy.; Clinica Medica, AOU Ospedali Riuniti di Ancona, Ancona, Italy., Longo V; Scleroderma Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Iandoli C; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Caserta, Italy., Cuomo G; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Caserta, Italy., Cuberli A; Unit of Rheumatology, Universita degli Studi di Padova Scuola di Medicina e Chirurgia, Padua, Italy., Zanatta E; DIMED, Universita degli Studi di Padova Dipartimento di Medicina, Padova, Italy., Lescoat A; Internal Medicine, CHU de Rennes, Rennes, France., Bellando-Randone S; Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy., Trignani G; Gaetano Pini-CTO, Milan, Italy.; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy., Guiducci S; Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy., Beretta L; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Moroncini G; Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy.; Clinica Medica, AOU Ospedali Riuniti di Ancona, Ancona, Italy., Giuggioli D; University of Modena and Reggio Emilia, Modena, Italy., Airò P; Rheumatology and Clinical Immunology, ASST Spedali Civili di Brescia, Brescia, Italy., Iannone F; Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, Università degli Studi di Bari Aldo Moro, Bari, Italy., Codullo V; SC Reumatologia, Università di Pavia, Pavia, Italy., Bosello SL; Rheumatology, Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Rome, Italy., Del Papa N; Scleroderma Clinic, Gaetano Pini-CTO, Milan, Italy., Truchetet ME; Rhumatologie, CHU Bordeaux GH Pellegrin, Bordeaux, France., Avouac J; Department of Rheumatology, Université Paris Cité, Cochin Institute, Paris, France., Dagna L; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases (UnIRAR), San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Matucci-Cerinic M; IRCCS and INFLAGE San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases (UnIRAR), San Raffaele Hospital, Milan, Italy.; Division of Clinical and Experimental Rheumatology l Medicine, Vita-Salute San Raffaele University, Milan, Italy., Allanore Y; Department of Rheumatology, Université Paris Cité, Cochin Institute, Paris, France yannick.allanore@aphp.fr., Campochiaro C; IRCCS and INFLAGE San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases (UnIRAR), San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.
Source: RMD open [RMD Open] 2026 Jun 09; Vol. 12 (2). Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101662038 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-5933 (Electronic) Linking ISSN: 20565933 NLM ISO Abbreviation: RMD Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and effectiveness of tocilizumab in systemic sclerosis: a multicentre French-Italian study.
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  Data: <searchLink fieldCode="AU" term="%22Buonsante+G%22">Buonsante G</searchLink>; IRCCS and INFLAGE San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.; Department of Rheumatology, Université Paris Cité, Cochin Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22De+Luca+G%22">De Luca G</searchLink>; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases (UnIRAR), San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Marazzi+E%22">Marazzi E</searchLink>; SC Reumatologia, Università di Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Cacciapaglia+F%22">Cacciapaglia F</searchLink>; Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, Università degli Studi di Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Lazzaroni+MG%22">Lazzaroni MG</searchLink>; Rheumatology and Clinical Immunology, ASST Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22De+Pinto+M%22">De Pinto M</searchLink>; Rheumatology, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Benfaremo+D%22">Benfaremo D</searchLink>; Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy.; Clinica Medica, AOU Ospedali Riuniti di Ancona, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Longo+V%22">Longo V</searchLink>; Scleroderma Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Iandoli+C%22">Iandoli C</searchLink>; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Caserta, Italy.<br /><searchLink fieldCode="AU" term="%22Cuomo+G%22">Cuomo G</searchLink>; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Caserta, Italy.<br /><searchLink fieldCode="AU" term="%22Cuberli+A%22">Cuberli A</searchLink>; Unit of Rheumatology, Universita degli Studi di Padova Scuola di Medicina e Chirurgia, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Zanatta+E%22">Zanatta E</searchLink>; DIMED, Universita degli Studi di Padova Dipartimento di Medicina, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Lescoat+A%22">Lescoat A</searchLink>; Internal Medicine, CHU de Rennes, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Bellando-Randone+S%22">Bellando-Randone S</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy.<br /><searchLink fieldCode="AU" term="%22Trignani+G%22">Trignani G</searchLink>; Gaetano Pini-CTO, Milan, Italy.; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Guiducci+S%22">Guiducci S</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy.<br /><searchLink fieldCode="AU" term="%22Beretta+L%22">Beretta L</searchLink>; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Moroncini+G%22">Moroncini G</searchLink>; Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy.; Clinica Medica, AOU Ospedali Riuniti di Ancona, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Giuggioli+D%22">Giuggioli D</searchLink>; University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Airò+P%22">Airò P</searchLink>; Rheumatology and Clinical Immunology, ASST Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Iannone+F%22">Iannone F</searchLink>; Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, Università degli Studi di Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Codullo+V%22">Codullo V</searchLink>; SC Reumatologia, Università di Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Bosello+SL%22">Bosello SL</searchLink>; Rheumatology, Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Del+Papa+N%22">Del Papa N</searchLink>; Scleroderma Clinic, Gaetano Pini-CTO, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Truchetet+ME%22">Truchetet ME</searchLink>; Rhumatologie, CHU Bordeaux GH Pellegrin, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Avouac+J%22">Avouac J</searchLink>; Department of Rheumatology, Université Paris Cité, Cochin Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dagna+L%22">Dagna L</searchLink>; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases (UnIRAR), San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Matucci-Cerinic+M%22">Matucci-Cerinic M</searchLink>; IRCCS and INFLAGE San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases (UnIRAR), San Raffaele Hospital, Milan, Italy.; Division of Clinical and Experimental Rheumatology l Medicine, Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Allanore+Y%22">Allanore Y</searchLink>; Department of Rheumatology, Université Paris Cité, Cochin Institute, Paris, France yannick.allanore@aphp.fr.<br /><searchLink fieldCode="AU" term="%22Campochiaro+C%22">Campochiaro C</searchLink>; IRCCS and INFLAGE San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases (UnIRAR), San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group%22">BMJ Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101662038 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2056-5933 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220565933%22">20565933 </searchLink><i>NLM ISO Abbreviation: </i>RMD Open <i>Subsets: </i>MEDLINE
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