Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner.

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Title: Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner.
Authors: Dexter TD; Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. tydexter@health.ucsd.edu.; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. tydexter@health.ucsd.edu., Machado MMF; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Hamidullah S; Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Palmer D; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Hashad AM; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Doyle M; Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Attard M; Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Allman BL; Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Inoue W; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Saksida LM; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Bussey TJ; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Psychiatry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Source: Nature communications [Nat Commun] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-73818-2