Corylin promotes healthy aging via RAGA-mTOR suppression and sex-dependent activation of SIRT3.

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Title: Corylin promotes healthy aging via RAGA-mTOR suppression and sex-dependent activation of SIRT3.
Authors: Cheng SF; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC., Lin YT; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ROC., Wang TH; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC.; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; Department of Hepato-Gastroenterology, Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; Graduate Institute of Health Industry Technology and Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC., Leu YL; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC.; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Hsia KC; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC., Lee WC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC.; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan, ROC., Feng CH; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC., Kuo CH; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan, ROC., Yang SH; School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Division of Chinese Internal Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Wang MC; School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Division of Chinese Gynecology Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Liu CY; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC., Hu PC; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC., Hsieh YC; Office of the Texas State Chemist, AgriLife Research, Texas A&M University System, College Station, TX, USA., Yang CW; Department of Nephrology and Kidney Research Center, School of Medicine, Chang Gung University, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Wang SH; Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Yu JS; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ROC. yusong@mail.cgu.edu.tw.; Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. yusong@mail.cgu.edu.tw.; Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC. yusong@mail.cgu.edu.tw., Chen CY; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. cychen@mail.cgust.edu.tw.; Graduate Institute of Health Industry Technology and Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC. cychen@mail.cgust.edu.tw., Chen CC; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC. chinchuan@mail.cgu.edu.tw.; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. chinchuan@mail.cgu.edu.tw.
Source: Nature communications [Nat Commun] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-74184-9