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Prolonged linezolid therapy induces progressive mitochondrial dysfunction in human peripheral blood mononuclear cells.

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Title: Prolonged linezolid therapy induces progressive mitochondrial dysfunction in human peripheral blood mononuclear cells.
Authors: Martínez-Guitián M; FarmaCHUSLab, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, 15706, Spain., Cajade-Pascual F; FarmaCHUSLab, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, 15706, Spain.; Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), Santiago de Compostela, 15706, Spain., Castro-Fernández DC; FarmaCHUSLab, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, 15706, Spain., Cuartero-Martínez A; FarmaCHUSLab, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, 15706, Spain., Nogueiras R; CIMUS, University of Santiago de Compostela- Health Research Institute of Santiago de Compostela, Santiago de Compostela, Galician, 15782, Spain.; Galician Agency of Innovation (GAIN), Xunta de Galicia, Santiago de Compostela, Spain., Fernández-Castro I; Internal Medicine Department, University Clinical Hospital of Santiago de Compostela (SERGAS), Santiago de Compostela, 15706, Spain., Molinos-Castro S; Internal Medicine Department, University Clinical Hospital of Santiago de Compostela (SERGAS), Santiago de Compostela, 15706, Spain., Ortea I; Proteomic Department, Center for Research in Nanomaterials and Nanotechnology (CINN-CSIC), Health Research Institute of Principado de Asturias (ISPA), Oviedo, Spain., Zarra-Ferro I; Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), Santiago de Compostela, 15706, Spain., González-Barcia M; FarmaCHUSLab, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, 15706, Spain.; Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), Santiago de Compostela, 15706, Spain., Fernández-Ferreiro A; FarmaCHUSLab, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, 15706, Spain. anxordes@gmail.com.; Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), Santiago de Compostela, 15706, Spain. anxordes@gmail.com., Mondelo-García C; FarmaCHUSLab, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, 15706, Spain. crismondelo1@gmail.com.; Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), Santiago de Compostela, 15706, Spain. crismondelo1@gmail.com.
Source: Journal of translational medicine [J Transl Med] 2026 Jun 09; Vol. 24 (1). Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1479-5876
DOI:10.1186/s12967-026-08406-5