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Loss of erythrocyte sialic acid in sepsis disrupts inhibitory Siglec interactions, driving neutrophil hyperactivation and NET outspread.

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Title: Loss of erythrocyte sialic acid in sepsis disrupts inhibitory Siglec interactions, driving neutrophil hyperactivation and NET outspread.
Authors: Such A; Department of Experimental Hematology, Faculty of Biology, Jagiellonian University, Krakow 30-387, Poland., Ortmann W; Department of Experimental Hematology, Faculty of Biology, Jagiellonian University, Krakow 30-387, Poland., Burczyk G; Department of Experimental Hematology, Faculty of Biology, Jagiellonian University, Krakow 30-387, Poland.; Doctoral School of Exact and Natural Sciences, Jagiellonian University, Krakow 30-348, Poland., Czepiel J; Department of Infectious Diseases, Faculty of Medicine, Jagiellonian University Medical College, Krakow 30-688, Poland., Bociaga-Jasik M; Department of Infectious Diseases, Faculty of Medicine, Jagiellonian University Medical College, Krakow 30-688, Poland., Link-Lenczowski P; Department of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow 31-126, Poland.; Center for the Development of Therapies for Civilization and Age-Related Diseases, Jagiellonian University Medical College, Krakow 31-066, Poland., Kolaczkowska E; Department of Experimental Hematology, Faculty of Biology, Jagiellonian University, Krakow 30-387, Poland.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 16; Vol. 123 (24), pp. e2536989123. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Loss of erythrocyte sialic acid in sepsis disrupts inhibitory Siglec interactions, driving neutrophil hyperactivation and NET outspread.
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  Data: <searchLink fieldCode="AU" term="%22Such+A%22">Such A</searchLink>; Department of Experimental Hematology, Faculty of Biology, Jagiellonian University, Krakow 30-387, Poland.<br /><searchLink fieldCode="AU" term="%22Ortmann+W%22">Ortmann W</searchLink>; Department of Experimental Hematology, Faculty of Biology, Jagiellonian University, Krakow 30-387, Poland.<br /><searchLink fieldCode="AU" term="%22Burczyk+G%22">Burczyk G</searchLink>; Department of Experimental Hematology, Faculty of Biology, Jagiellonian University, Krakow 30-387, Poland.; Doctoral School of Exact and Natural Sciences, Jagiellonian University, Krakow 30-348, Poland.<br /><searchLink fieldCode="AU" term="%22Czepiel+J%22">Czepiel J</searchLink>; Department of Infectious Diseases, Faculty of Medicine, Jagiellonian University Medical College, Krakow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Bociaga-Jasik+M%22">Bociaga-Jasik M</searchLink>; Department of Infectious Diseases, Faculty of Medicine, Jagiellonian University Medical College, Krakow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Link-Lenczowski+P%22">Link-Lenczowski P</searchLink>; Department of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow 31-126, Poland.; Center for the Development of Therapies for Civilization and Age-Related Diseases, Jagiellonian University Medical College, Krakow 31-066, Poland.<br /><searchLink fieldCode="AU" term="%22Kolaczkowska+E%22">Kolaczkowska E</searchLink>; Department of Experimental Hematology, Faculty of Biology, Jagiellonian University, Krakow 30-387, Poland.
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              Text: 2026 Jun 16
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