The germline MLH1 c.2054 C>T mutation disrupts DNA mismatch repair and is detectable by digital PCR.
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| Title: | The germline MLH1 c.2054 C>T mutation disrupts DNA mismatch repair and is detectable by digital PCR. |
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| Authors: | Moldenhauer MR; School of Medicine, University of California Irvine, Irvine, CA, USA., Mahadevan A; School of Medicine, University of California Irvine, Irvine, CA, USA., Hom C; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Nguyen ATM; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Rangel V; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Hasson S; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA., Hsu NH; School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Ubbaonu C; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA., Nathan D; School of Medicine, University of California Irvine, Irvine, CA, USA., Chandan VS; School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Pathology, University of California, Irvine, Orange, CA, USA., Shen KV; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California, Irvine, CA, USA., Damozonio EM; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Zhou GG; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA., Chichili T; Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Le A; Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Masri S; School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA., Dayyani F; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA., Qiao F; School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA., Valerin JB; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA. Electronic address: jvalerin@hs.uci.edu., Pannunzio NR; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA. Electronic address: nrpann@hs.uci.edu. |
| Source: | Cancer letters [Cancer Lett] 2026 Sep 28; Vol. 656, pp. 218669. Date of Electronic Publication: 2026 Jun 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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