In vivo base editing alleviates hepatic iron accumulation and fibrosis in models of HFE-related hereditary hemochromatosis.

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Title: In vivo base editing alleviates hepatic iron accumulation and fibrosis in models of HFE-related hereditary hemochromatosis.
Authors: Hamann V; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Hook S; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Sujariyakul P; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Ramalingam R; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Sgodda M; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Klefenz I; Department of Human Genetics, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Stalke A; Department of Human Genetics, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Yuan Q; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; Sino-German Center for Cell and Gene Therapy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Steinbrück L; Institute of Virology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Rovai A; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany., Ruhe M; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Chung BM; Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany., Steinemann D; Department of Human Genetics, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Sharma AD; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Cantz T; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Lin PJC; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Wedemeyer H; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Ott M; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; Sino-German Center for Cell and Gene Therapy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. Electronic address: Ott.Michael@mh-hannover.de., Krooss SA; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; PRACTIS Clinician Scientist Program, Dean's Office for Academic Career Development, Hannover Medical School, Hannover, Germany. Electronic address: Krooss.Simon@mh-hannover.de.
Source: Journal of hepatology [J Hepatol] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1600-0641
DOI:10.1016/j.jhep.2026.05.022