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In vivo base editing alleviates hepatic iron accumulation and fibrosis in models of HFE-related hereditary hemochromatosis.

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Title: In vivo base editing alleviates hepatic iron accumulation and fibrosis in models of HFE-related hereditary hemochromatosis.
Authors: Hamann V; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Hook S; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Sujariyakul P; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Ramalingam R; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Sgodda M; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Klefenz I; Department of Human Genetics, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Stalke A; Department of Human Genetics, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Yuan Q; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; Sino-German Center for Cell and Gene Therapy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Steinbrück L; Institute of Virology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Rovai A; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany., Ruhe M; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Chung BM; Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany., Steinemann D; Department of Human Genetics, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Sharma AD; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Cantz T; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Lin PJC; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Wedemeyer H; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany., Ott M; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; Sino-German Center for Cell and Gene Therapy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. Electronic address: Ott.Michael@mh-hannover.de., Krooss SA; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; PRACTIS Clinician Scientist Program, Dean's Office for Academic Career Development, Hannover Medical School, Hannover, Germany. Electronic address: Krooss.Simon@mh-hannover.de.
Source: Journal of hepatology [J Hepatol] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In vivo base editing alleviates hepatic iron accumulation and fibrosis in models of HFE-related hereditary hemochromatosis.
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  Data: <searchLink fieldCode="AU" term="%22Hamann+V%22">Hamann V</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Hook+S%22">Hook S</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Sujariyakul+P%22">Sujariyakul P</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Ramalingam+R%22">Ramalingam R</searchLink>; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Sgodda+M%22">Sgodda M</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Klefenz+I%22">Klefenz I</searchLink>; Department of Human Genetics, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Stalke+A%22">Stalke A</searchLink>; Department of Human Genetics, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Yuan+Q%22">Yuan Q</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; Sino-German Center for Cell and Gene Therapy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.<br /><searchLink fieldCode="AU" term="%22Steinbrück+L%22">Steinbrück L</searchLink>; Institute of Virology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Rovai+A%22">Rovai A</searchLink>; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Ruhe+M%22">Ruhe M</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Chung+BM%22">Chung BM</searchLink>; Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Steinemann+D%22">Steinemann D</searchLink>; Department of Human Genetics, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Sharma+AD%22">Sharma AD</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Cantz+T%22">Cantz T</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Lin+PJC%22">Lin PJC</searchLink>; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Wedemeyer+H%22">Wedemeyer H</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Ott+M%22">Ott M</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; Sino-German Center for Cell and Gene Therapy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. Electronic address: Ott.Michael@mh-hannover.de.<br /><searchLink fieldCode="AU" term="%22Krooss+SA%22">Krooss SA</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; PRACTIS Clinician Scientist Program, Dean's Office for Academic Career Development, Hannover Medical School, Hannover, Germany. Electronic address: Krooss.Simon@mh-hannover.de.
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        Value: 10.1016/j.jhep.2026.05.022
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