Mechanically heterogeneous nanofibrous hydrogel drives Piezo1-mediated cell aggregation and collective migration.

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Title: Mechanically heterogeneous nanofibrous hydrogel drives Piezo1-mediated cell aggregation and collective migration.
Authors: Song H; Liaoning Key Laboratory of Protein Modification and Disease, MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China., Chao Z; Liaoning Key Laboratory of Protein Modification and Disease, MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China., Guo Q; Liaoning Key Laboratory of Protein Modification and Disease, MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China., Qi Y; Liaoning Key Laboratory of Protein Modification and Disease, MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China., Zhang Y; Liaoning Key Laboratory of Protein Modification and Disease, MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China., Wang X; Liaoning Key Laboratory of Protein Modification and Disease, MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China., Xu J; Liaoning Key Laboratory of Protein Modification and Disease, MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China., Liu Y; Department of Clinical Laboratory, Central Hospital of Dalian University of Technology, Dalian Municipal Central Hospital, Dalian, China., Qiao W; Department of Clinical Laboratory, Central Hospital of Dalian University of Technology, Dalian Municipal Central Hospital, Dalian, China., Jia L; Liaoning Key Laboratory of Protein Modification and Disease, MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China. Electronic address: lyj81@dlut.edu.cn., Han L; Liaoning Key Laboratory of Protein Modification and Disease, MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China. Electronic address: luluhan@dlut.edu.cn.
Source: Acta biomaterialia [Acta Biomater] 2026 Jul; Vol. 218, pp. 244-260. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-7568
DOI:10.1016/j.actbio.2026.06.018