O-linked glycan-dependent gating of TPC2 controls lysosomal excitability and organelle remodeling.

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Title: O-linked glycan-dependent gating of TPC2 controls lysosomal excitability and organelle remodeling.
Authors: Lin A; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Lin NY; Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan., Keller M; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University, Munich, Germany., Schütz R; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University, Munich, Germany., Wu YZ; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Burton W; Department of Pharmacology, University of Oxford, Oxford, UK., Kinanti NP; Department of Biomedical Sciences and Engineering, Tzu Chi University, Hualien, Taiwan., Yao CY; Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan., Urban N; Rudolf-Boehm-Institute of Pharmacology and Toxicology, Leipzig University, Leipzig, Germany., Liu YW; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan., Bracher F; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University, Munich, Germany., Galione A; Department of Pharmacology, University of Oxford, Oxford, UK., Hsu HJ; Department of Biomedical Sciences and Engineering, Tzu Chi University, Hualien, Taiwan., Kuo CY; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chen CC; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan. chenchengchang@ntu.edu.tw.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan. chenchengchang@ntu.edu.tw.
Source: Nature communications [Nat Commun] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-74268-6