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Defective inducible T cell costimulator signalling drives neuropilin-1hi CD4+ T cell-mediated non-germinal centre B cell activation via impaired regulatory T cell maintenance in a lupus model.

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Title: Defective inducible T cell costimulator signalling drives neuropilin-1hi CD4+ T cell-mediated non-germinal centre B cell activation via impaired regulatory T cell maintenance in a lupus model.
Authors: Kang S; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea., Kim DE; Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea., Kim N; Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea., O E; Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea., Yoon HJ; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea., Joo Y; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea., Hong SW; Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. hongsw@yonsei.ac.kr.; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea. hongsw@yonsei.ac.kr., Kim KS; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. kskim27@postech.ac.kr.; Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. kskim27@postech.ac.kr.
Source: Experimental & molecular medicine [Exp Mol Med] 2026 Jun; Vol. 58 (6), pp. 1971-1986. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9607880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2092-6413 (Electronic) Linking ISSN: 12263613 NLM ISO Abbreviation: Exp Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2092-6413
DOI:10.1038/s12276-026-01756-6