The promyelocytic leukemia PML protein coordinates immune evasion in triple-negative breast cancer via independent and converging mechanisms.

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Title: The promyelocytic leukemia PML protein coordinates immune evasion in triple-negative breast cancer via independent and converging mechanisms.
Authors: Uggè M; Mechanisms of Non-oncogene Addiction in Cancer Unit, Comprehensive Cancer Center, IRCCS Ospedale San Raffaele, Milan, Italy., Fracassi C; Mechanisms of Non-oncogene Addiction in Cancer Unit, Comprehensive Cancer Center, IRCCS Ospedale San Raffaele, Milan, Italy.; Institute of Human Genetics (IGH), University of Montpellier, CNRS, Montpellier, France., Tascini AS; Center for Omics Sciences COSR, IRCCS Ospedale San Raffaele, Milan, Italy., Giansanti V; Center for Omics Sciences COSR, IRCCS Ospedale San Raffaele, Milan, Italy., Genova F; Center for Omics Sciences COSR, IRCCS Ospedale San Raffaele, Milan, Italy., Dugo M; Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy., Giannese F; Center for Omics Sciences COSR, IRCCS Ospedale San Raffaele, Milan, Italy., Basso V; Lymphocyte Activation Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Ghirardi C; Department of Molecular Oncology, European Institute of Oncology (IEO) IRCCS, Milan, Italy., Smart CE; Pathology Unit, Università Vita-Salute San Raffaele, Milan, Italy.; Cairns and Hinterland Hospital and Health Service, Queensland Health, Cairns, QLD, Australia., Doglioni C; Pathology Unit, Università Vita-Salute San Raffaele, Milan, Italy., Casorati G; Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Dellabona P; Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Zambelli S; Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy., Servitja Tormo S; GEICAM Spanish Breast Cancer Group, Madrid, Spain.; Oncology Department, Hospital del Mar, Barcelona, Spain., Cruz Jurado J; GEICAM Spanish Breast Cancer Group, Madrid, Spain.; Oncology Department, Hospital Universitario de Canarias, Tenerife, Spain., Gianni L; Fondazione Michelangelo, Milan, Italy., Bonaldi T; Department of Molecular Oncology, European Institute of Oncology (IEO) IRCCS, Milan, Italy.; Department of Oncology and Haemato-Oncology, University of Milan, Milan, Italy., Agresti A; Mechanisms of Non-oncogene Addiction in Cancer Unit, Comprehensive Cancer Center, IRCCS Ospedale San Raffaele, Milan, Italy., Mondino A; Lymphocyte Activation Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Bianchini G; Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.; Università Vita-Salute San Raffaele, Milan, Italy., Bernardi R; Mechanisms of Non-oncogene Addiction in Cancer Unit, Comprehensive Cancer Center, IRCCS Ospedale San Raffaele, Milan, Italy. bernardi.rosa@hsr.it.
Source: Cell death and differentiation [Cell Death Differ] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
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  Data: The promyelocytic leukemia PML protein coordinates immune evasion in triple-negative breast cancer via independent and converging mechanisms.
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  Data: <searchLink fieldCode="AU" term="%22Uggè+M%22">Uggè M</searchLink>; Mechanisms of Non-oncogene Addiction in Cancer Unit, Comprehensive Cancer Center, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fracassi+C%22">Fracassi C</searchLink>; Mechanisms of Non-oncogene Addiction in Cancer Unit, Comprehensive Cancer Center, IRCCS Ospedale San Raffaele, Milan, Italy.; Institute of Human Genetics (IGH), University of Montpellier, CNRS, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Tascini+AS%22">Tascini AS</searchLink>; Center for Omics Sciences COSR, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Giansanti+V%22">Giansanti V</searchLink>; Center for Omics Sciences COSR, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Genova+F%22">Genova F</searchLink>; Center for Omics Sciences COSR, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Dugo+M%22">Dugo M</searchLink>; Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Giannese+F%22">Giannese F</searchLink>; Center for Omics Sciences COSR, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Basso+V%22">Basso V</searchLink>; Lymphocyte Activation Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ghirardi+C%22">Ghirardi C</searchLink>; Department of Molecular Oncology, European Institute of Oncology (IEO) IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Smart+CE%22">Smart CE</searchLink>; Pathology Unit, Università Vita-Salute San Raffaele, Milan, Italy.; Cairns and Hinterland Hospital and Health Service, Queensland Health, Cairns, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Doglioni+C%22">Doglioni C</searchLink>; Pathology Unit, Università Vita-Salute San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Casorati+G%22">Casorati G</searchLink>; Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Dellabona+P%22">Dellabona P</searchLink>; Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Zambelli+S%22">Zambelli S</searchLink>; Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Servitja+Tormo+S%22">Servitja Tormo S</searchLink>; GEICAM Spanish Breast Cancer Group, Madrid, Spain.; Oncology Department, Hospital del Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Cruz+Jurado+J%22">Cruz Jurado J</searchLink>; GEICAM Spanish Breast Cancer Group, Madrid, Spain.; Oncology Department, Hospital Universitario de Canarias, Tenerife, Spain.<br /><searchLink fieldCode="AU" term="%22Gianni+L%22">Gianni L</searchLink>; Fondazione Michelangelo, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bonaldi+T%22">Bonaldi T</searchLink>; Department of Molecular Oncology, European Institute of Oncology (IEO) IRCCS, Milan, Italy.; Department of Oncology and Haemato-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Agresti+A%22">Agresti A</searchLink>; Mechanisms of Non-oncogene Addiction in Cancer Unit, Comprehensive Cancer Center, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mondino+A%22">Mondino A</searchLink>; Lymphocyte Activation Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bianchini+G%22">Bianchini G</searchLink>; Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.; Università Vita-Salute San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bernardi+R%22">Bernardi R</searchLink>; Mechanisms of Non-oncogene Addiction in Cancer Unit, Comprehensive Cancer Center, IRCCS Ospedale San Raffaele, Milan, Italy. bernardi.rosa@hsr.it.
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