S100A10-ANXA2 tetramer inhibition hampers hepatic stellate cell activation in human MASLD organoids.

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Title: S100A10-ANXA2 tetramer inhibition hampers hepatic stellate cell activation in human MASLD organoids.
Authors: Türkal M; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Faculty of Medicine, Diabetes Center, University of Geneva, Geneva, Switzerland., Maeder C; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Faculty of Medicine, Diabetes Center, University of Geneva, Geneva, Switzerland., Correia de Sousa M; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Faculty of Medicine, Diabetes Center, University of Geneva, Geneva, Switzerland., Fournier M; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Faculty of Medicine, Diabetes Center, University of Geneva, Geneva, Switzerland., El-Harane S; Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Gjorgjieva M; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Faculty of Medicine, Diabetes Center, University of Geneva, Geneva, Switzerland., Foti M; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Faculty of Medicine, Diabetes Center, University of Geneva, Geneva, Switzerland., Maecher P; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Pierre.maechler@unige.ch.; Faculty of Medicine, Diabetes Center, University of Geneva, Geneva, Switzerland. Pierre.maechler@unige.ch., Delangre E; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Etienne.delangre@unige.ch.; Faculty of Medicine, Diabetes Center, University of Geneva, Geneva, Switzerland. Etienne.delangre@unige.ch.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jul; Vol. 18 (7), pp. 2920-2945. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1757-4684
DOI:10.1038/s44321-026-00464-y