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FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets.

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Title: FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets.
Authors: Parekh P; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, California, United States of America., Parker N; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway., Pecheva D; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, California, United States of America., Frei E; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway., Vaudel M; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Computational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.; Department of Genetics and Bioinformatics, Norwegian Institute of Public Health, Bergen, Norway., Smith DM; Center for Human Development, University of California San Diego, La Jolla, California, United States of America.; Medical Scientist Training Program, University of California San Diego, La Jolla, California, United States of America., Rigby A; Neuroscience Graduate Program, University of California San Diego, La Jolla, California, United States of America., Jahołkowski P; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway., Sønderby IE; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital & University of Oslo, Oslo, Norway., Birkenæs V; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.; PsychGen Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway., Bakken NR; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.; PsychGen Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway., Fan CC; Center for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, Oklahoma, United States of America., Makowski C; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California, United States of America., Kopal J; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway., Loughnan R; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, California, United States of America.; Population Neuroscience and Genetics Lab, University of California San Diego, La Jolla, California, United States of America., Hagler DJ Jr; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, California, United States of America., van der Meer D; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway., Johansson S; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics and Adolescents, Haukeland University Hospital, Bergen, Norway., Njølstad PR; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics and Adolescents, Haukeland University Hospital, Bergen, Norway., Jernigan TL; Department of Radiology, School of Medicine, University of California San Diego, La Jolla, California, United States of America.; Center for Human Development, University of California San Diego, La Jolla, California, United States of America.; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California, United States of America.; Department of Cognitive Science, University of California San Diego, La Jolla, California, United States of America., Thompson WK; Center for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, Oklahoma, United States of America., Frei O; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.; Department of Pharmacy, Section for Pharmacology and Pharmaceutical Biosciences, University of Oslo, Oslo, Norway., Shadrin AA; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway., Nichols TE; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Andreassen OA; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway., Dale AM; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, California, United States of America.; University of California San Diego, La Jolla, California, United States of America.; University of Oslo, Oslo, Norway.
Source: PLoS genetics [PLoS Genet] 2026 Jun 11; Vol. 22 (6), pp. e1012184. Date of Electronic Publication: 2026 Jun 11 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE
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  Data: FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets.
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  Data: <searchLink fieldCode="AU" term="%22Parekh+P%22">Parekh P</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Parker+N%22">Parker N</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Pecheva+D%22">Pecheva D</searchLink>; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Frei+E%22">Frei E</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Vaudel+M%22">Vaudel M</searchLink>; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Computational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.; Department of Genetics and Bioinformatics, Norwegian Institute of Public Health, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Smith+DM%22">Smith DM</searchLink>; Center for Human Development, University of California San Diego, La Jolla, California, United States of America.; Medical Scientist Training Program, University of California San Diego, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Rigby+A%22">Rigby A</searchLink>; Neuroscience Graduate Program, University of California San Diego, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Jahołkowski+P%22">Jahołkowski P</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Sønderby+IE%22">Sønderby IE</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital & University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Birkenæs+V%22">Birkenæs V</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.; PsychGen Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Bakken+NR%22">Bakken NR</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.; PsychGen Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Fan+CC%22">Fan CC</searchLink>; Center for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, Oklahoma, United States of America.<br /><searchLink fieldCode="AU" term="%22Makowski+C%22">Makowski C</searchLink>; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Kopal+J%22">Kopal J</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Loughnan+R%22">Loughnan R</searchLink>; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, California, United States of America.; Population Neuroscience and Genetics Lab, University of California San Diego, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Hagler+DJ+Jr%22">Hagler DJ Jr</searchLink>; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22van+der+Meer+D%22">van der Meer D</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Johansson+S%22">Johansson S</searchLink>; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics and Adolescents, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Njølstad+PR%22">Njølstad PR</searchLink>; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics and Adolescents, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Jernigan+TL%22">Jernigan TL</searchLink>; Department of Radiology, School of Medicine, University of California San Diego, La Jolla, California, United States of America.; Center for Human Development, University of California San Diego, La Jolla, California, United States of America.; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California, United States of America.; Department of Cognitive Science, University of California San Diego, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Thompson+WK%22">Thompson WK</searchLink>; Center for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, Oklahoma, United States of America.<br /><searchLink fieldCode="AU" term="%22Frei+O%22">Frei O</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.; Department of Pharmacy, Section for Pharmacology and Pharmaceutical Biosciences, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Shadrin+AA%22">Shadrin AA</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Nichols+TE%22">Nichols TE</searchLink>; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Andreassen+OA%22">Andreassen OA</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Dale+AM%22">Dale AM</searchLink>; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, California, United States of America.; University of California San Diego, La Jolla, California, United States of America.; University of Oslo, Oslo, Norway.
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