Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders.

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Title: Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders.
Authors: Jovanovic VM; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA. Electronic address: vukasin.jovanovic@nih.gov., Narisu N; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Bonnycastle LL; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Castellano D; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Ryu S; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Tharakan R; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Mesch KT; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Chen Q; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Betül Erol FM; Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Glover HJ; Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Yan T; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Sinha N; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Sen C; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Yang S; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Blivis D; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Bennett DF; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD, USA., Rosales-Soto G; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD, USA., Inman J; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Ormanoglu P; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., LeClair CA; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Shaw ND; Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Xia M; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Schneider M; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD, USA., Hernandez-Ochoa EO; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD, USA., Erdos MR; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Simeonov A; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Chen S; Department of Surgery, Center for Genomic Health, Weill Cornell Medicine, New York, NY 10065, USA., Collins FS; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Doege CA; Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Tristan CA; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA. Electronic address: carlos.tristan@nih.gov.
Source: Stem cell reports [Stem Cell Reports] 2026 Jul 14; Vol. 21 (7), pp. 102958. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2213-6711
DOI:10.1016/j.stemcr.2026.102958