IL11 modulates MMP12 expression and cancer cell metastasis via IL11RA/IL6ST-PI3K/Akt/NF-κB pathway in lung cancer.

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Title: IL11 modulates MMP12 expression and cancer cell metastasis via IL11RA/IL6ST-PI3K/Akt/NF-κB pathway in lung cancer.
Authors: Lee CW; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan, ROC.; Department of Safety Health and Environmental Engineering, Ming Chi University of Technology, New Taipei City, Taiwan, ROC., Lin SS; Division of Chest Medicine, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC., Chang TM; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan, ROC., Lin ZC; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC., Chiang YC; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC., Chi MC; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan, ROC., Peng KT; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan, ROC.; College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC., Fang ML; Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung, Taiwan, ROC.; Department of Civil Engineering and Geomatics, Cheng Shiu University, Kaohsiung, Taiwan, ROC., Liu JF; Translational Medicine Center, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC. jufangliu@tmu.edu.tw.; School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan, ROC. jufangliu@tmu.edu.tw.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC. jufangliu@tmu.edu.tw.
Source: Cell death discovery [Cell Death Discov] 2026 Jun 11. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov
Database: MEDLINE Ultimate
Description
ISSN:2058-7716
DOI:10.1038/s41420-026-03163-2