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IL11 modulates MMP12 expression and cancer cell metastasis via IL11RA/IL6ST-PI3K/Akt/NF-κB pathway in lung cancer.

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Title: IL11 modulates MMP12 expression and cancer cell metastasis via IL11RA/IL6ST-PI3K/Akt/NF-κB pathway in lung cancer.
Authors: Lee CW; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan, ROC.; Department of Safety Health and Environmental Engineering, Ming Chi University of Technology, New Taipei City, Taiwan, ROC., Lin SS; Division of Chest Medicine, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC., Chang TM; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan, ROC., Lin ZC; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC., Chiang YC; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC., Chi MC; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan, ROC., Peng KT; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan, ROC.; College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC., Fang ML; Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung, Taiwan, ROC.; Department of Civil Engineering and Geomatics, Cheng Shiu University, Kaohsiung, Taiwan, ROC., Liu JF; Translational Medicine Center, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC. jufangliu@tmu.edu.tw.; School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan, ROC. jufangliu@tmu.edu.tw.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC. jufangliu@tmu.edu.tw.
Source: Cell death discovery [Cell Death Discov] 2026 Jun 11. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov
Database: MEDLINE Ultimate
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  Data: IL11 modulates MMP12 expression and cancer cell metastasis via IL11RA/IL6ST-PI3K/Akt/NF-κB pathway in lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Lee+CW%22">Lee CW</searchLink>; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan, ROC.; Department of Safety Health and Environmental Engineering, Ming Chi University of Technology, New Taipei City, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Lin+SS%22">Lin SS</searchLink>; Division of Chest Medicine, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Chang+TM%22">Chang TM</searchLink>; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Lin+ZC%22">Lin ZC</searchLink>; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Chiang+YC%22">Chiang YC</searchLink>; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Chi+MC%22">Chi MC</searchLink>; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC.; Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Peng+KT%22">Peng KT</searchLink>; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan, ROC.; College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Fang+ML%22">Fang ML</searchLink>; Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung, Taiwan, ROC.; Department of Civil Engineering and Geomatics, Cheng Shiu University, Kaohsiung, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Liu+JF%22">Liu JF</searchLink>; Translational Medicine Center, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC. jufangliu@tmu.edu.tw.; School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan, ROC. jufangliu@tmu.edu.tw.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC. jufangliu@tmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2026 Jun 11. <i>Date of Electronic Publication: </i>2026 Jun 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov
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        Value: 10.1038/s41420-026-03163-2
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        Text: English
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            – D: 11
              M: 06
              Text: 2026 Jun 11
              Type: published
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