Critical illness expands a transcriptionally distinct hypometabolic CD8+ T effector program associated with respiratory failure and mortality.

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Title: Critical illness expands a transcriptionally distinct hypometabolic CD8+ T effector program associated with respiratory failure and mortality.
Authors: Nichols CM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Mwizerwa EL; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sim CY; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Obeidalla SN; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Cephus JY; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Roe CE; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.; Department of Pediatrics-Neurology, University of Colorado Anschutz Medical Campus, Denver CO, USA., Irish JM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.; Department of Pediatrics-Neurology, University of Colorado Anschutz Medical Campus, Denver CO, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Newcomb DC; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA., Kerchberger VE; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Bastarache JA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Rathmell JC; Ben May Department of Cancer Research, University of Chicago, Chicago, IL, USA., Ware LB; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Stier MT; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jun 02. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.05.28.728555