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Critical illness expands a transcriptionally distinct hypometabolic CD8+ T effector program associated with respiratory failure and mortality.

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Title: Critical illness expands a transcriptionally distinct hypometabolic CD8+ T effector program associated with respiratory failure and mortality.
Authors: Nichols CM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Mwizerwa EL; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sim CY; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Obeidalla SN; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Cephus JY; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Roe CE; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.; Department of Pediatrics-Neurology, University of Colorado Anschutz Medical Campus, Denver CO, USA., Irish JM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.; Department of Pediatrics-Neurology, University of Colorado Anschutz Medical Campus, Denver CO, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Newcomb DC; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA., Kerchberger VE; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Bastarache JA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Rathmell JC; Ben May Department of Cancer Research, University of Chicago, Chicago, IL, USA., Ware LB; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Stier MT; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jun 02. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Critical illness expands a transcriptionally distinct hypometabolic CD8<superscript>+</superscript> T effector program associated with respiratory failure and mortality.
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  Data: <searchLink fieldCode="AU" term="%22Nichols+CM%22">Nichols CM</searchLink>; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Mwizerwa+EL%22">Mwizerwa EL</searchLink>; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Sim+CY%22">Sim CY</searchLink>; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Obeidalla+SN%22">Obeidalla SN</searchLink>; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cephus+JY%22">Cephus JY</searchLink>; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Roe+CE%22">Roe CE</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.; Department of Pediatrics-Neurology, University of Colorado Anschutz Medical Campus, Denver CO, USA.<br /><searchLink fieldCode="AU" term="%22Irish+JM%22">Irish JM</searchLink>; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.; Department of Pediatrics-Neurology, University of Colorado Anschutz Medical Campus, Denver CO, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Newcomb+DC%22">Newcomb DC</searchLink>; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Kerchberger+VE%22">Kerchberger VE</searchLink>; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bastarache+JA%22">Bastarache JA</searchLink>; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Rathmell+JC%22">Rathmell JC</searchLink>; Ben May Department of Cancer Research, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Ware+LB%22">Ware LB</searchLink>; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Stier+MT%22">Stier MT</searchLink>; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.
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        Value: 10.64898/2026.05.28.728555
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        Text: English
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              Text: 2026 Jun 02
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