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EZH1/2 inhibition improves immunotherapy response through MHC Class II de-repression and neutrophil reprogramming.

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Title: EZH1/2 inhibition improves immunotherapy response through MHC Class II de-repression and neutrophil reprogramming.
Authors: Childress AR; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States., Esoe DP; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States., Song X; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States., Gosser CM; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States., Lin Y; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States., Plaugher DR; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States., DuCote TJ; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States., Naughton KJ; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States., Skaggs EM; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States., Yang H; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States., Goettl R; Markey Cancer Center, University of Kentucky, Lexington KY, United States., Liu J; Markey Cancer Center, University of Kentucky, Lexington KY, United States.; Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States., Hao Z; Markey Cancer Center, University of Kentucky, Lexington KY, United States.; Division of Oncology, Department of Internal Medicine, University of Kentucky, Lexington KY, United States., Fliss AE; Daiichi Sankyo, Co., Ltd, Basking Ridge, NJ, United States., Honma D; Oncology Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan., Burus T; Markey Cancer Center, University of Kentucky, Lexington KY, United States.; Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.; Kentucky Cancer Registry, Markey Cancer Center, University of Kentucky, Lexington KY, United States., Lei F; Markey Cancer Center, University of Kentucky, Lexington KY, United States.; Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.; Kentucky Cancer Registry, Markey Cancer Center, University of Kentucky, Lexington KY, United States., Huang B; Markey Cancer Center, University of Kentucky, Lexington KY, United States.; Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.; Kentucky Cancer Registry, Markey Cancer Center, University of Kentucky, Lexington KY, United States., Beswick EJ; Division of Molecular Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, United States., Brainson CF; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States.; Markey Cancer Center, University of Kentucky, Lexington KY, United States.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jul 02. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: EZH1/2 inhibition improves immunotherapy response through MHC Class II de-repression and neutrophil reprogramming.
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  Data: <searchLink fieldCode="AU" term="%22Childress+AR%22">Childress AR</searchLink>; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Esoe+DP%22">Esoe DP</searchLink>; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Song+X%22">Song X</searchLink>; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Gosser+CM%22">Gosser CM</searchLink>; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Lin+Y%22">Lin Y</searchLink>; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Plaugher+DR%22">Plaugher DR</searchLink>; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22DuCote+TJ%22">DuCote TJ</searchLink>; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Naughton+KJ%22">Naughton KJ</searchLink>; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Skaggs+EM%22">Skaggs EM</searchLink>; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Goettl+R%22">Goettl R</searchLink>; Markey Cancer Center, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Markey Cancer Center, University of Kentucky, Lexington KY, United States.; Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.<br /><searchLink fieldCode="AU" term="%22Hao+Z%22">Hao Z</searchLink>; Markey Cancer Center, University of Kentucky, Lexington KY, United States.; Division of Oncology, Department of Internal Medicine, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Fliss+AE%22">Fliss AE</searchLink>; Daiichi Sankyo, Co., Ltd, Basking Ridge, NJ, United States.<br /><searchLink fieldCode="AU" term="%22Honma+D%22">Honma D</searchLink>; Oncology Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Burus+T%22">Burus T</searchLink>; Markey Cancer Center, University of Kentucky, Lexington KY, United States.; Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.; Kentucky Cancer Registry, Markey Cancer Center, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Lei+F%22">Lei F</searchLink>; Markey Cancer Center, University of Kentucky, Lexington KY, United States.; Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.; Kentucky Cancer Registry, Markey Cancer Center, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Huang+B%22">Huang B</searchLink>; Markey Cancer Center, University of Kentucky, Lexington KY, United States.; Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.; Kentucky Cancer Registry, Markey Cancer Center, University of Kentucky, Lexington KY, United States.<br /><searchLink fieldCode="AU" term="%22Beswick+EJ%22">Beswick EJ</searchLink>; Division of Molecular Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.<br /><searchLink fieldCode="AU" term="%22Brainson+CF%22">Brainson CF</searchLink>; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington KY, United States.; Markey Cancer Center, University of Kentucky, Lexington KY, United States.
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        Value: 10.64898/2026.06.01.725956
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