Limited efficacy of a therapeutic anti-CD40 monoclonal antibody to inhibit activated CD4 T cell autoimmunity in vitro.

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Title: Limited efficacy of a therapeutic anti-CD40 monoclonal antibody to inhibit activated CD4 T cell autoimmunity in vitro.
Authors: Gootjes C; Department of Internal Medicine, Section Immunomodulation and Regenerative Cell Therapy, Leiden University Medical Center, Leiden, The Netherlands., Zwaginga JJ; Department of Internal Medicine, Section Immunomodulation and Regenerative Cell Therapy, Leiden University Medical Center, Leiden, The Netherlands., Nikolic T; Department of Internal Medicine, Section Immunomodulation and Regenerative Cell Therapy, Leiden University Medical Center, Leiden, The Netherlands., Roep BO; Department of Internal Medicine, Section Immunomodulation and Regenerative Cell Therapy, Leiden University Medical Center, Leiden, The Netherlands.
Source: PloS one [PLoS One] 2026 Jun 12; Vol. 21 (6), pp. e0351131. Date of Electronic Publication: 2026 Jun 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1932-6203
DOI:10.1371/journal.pone.0351131