In silico prioritization and cheminformatics identify structurally diverse small-molecule inhibitors of Lassa virus glycoprotein-mediated membrane fusion.

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Title: In silico prioritization and cheminformatics identify structurally diverse small-molecule inhibitors of Lassa virus glycoprotein-mediated membrane fusion.
Authors: Close BJ; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA., La Rosa B; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA., Ong C; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA., Anantpadma M; Pfizer, 301 Middletown Road, Pearl River, NY 10965, USA., Elkabbany AH; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, IN 47907, USA; Department of Chemistry, Massachusetts College of Liberal Arts, North Adams, MA 01247, USA., Stubbs SH; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA., Davisson VJ; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, IN 47907, USA., Davey RA; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA. Electronic address: radavey@bu.edu.
Source: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2026 Sep; Vol. 42, pp. 100319. Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2472-5560
DOI:10.1016/j.slasd.2026.100319