In silico prioritization and cheminformatics identify structurally diverse small-molecule inhibitors of Lassa virus glycoprotein-mediated membrane fusion.
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| Title: | In silico prioritization and cheminformatics identify structurally diverse small-molecule inhibitors of Lassa virus glycoprotein-mediated membrane fusion. |
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| Authors: | Close BJ; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA., La Rosa B; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA., Ong C; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA., Anantpadma M; Pfizer, 301 Middletown Road, Pearl River, NY 10965, USA., Elkabbany AH; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, IN 47907, USA; Department of Chemistry, Massachusetts College of Liberal Arts, North Adams, MA 01247, USA., Stubbs SH; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA., Davisson VJ; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, IN 47907, USA., Davey RA; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA. Electronic address: radavey@bu.edu. |
| Source: | SLAS discovery : advancing life sciences R & D [SLAS Discov] 2026 Sep; Vol. 42, pp. 100319. Date of Electronic Publication: 2026 Jun 12. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42285356 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: In silico prioritization and cheminformatics identify structurally diverse small-molecule inhibitors of Lassa virus glycoprotein-mediated membrane fusion. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Close+BJ%22">Close BJ</searchLink>; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22La+Rosa+B%22">La Rosa B</searchLink>; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Ong+C%22">Ong C</searchLink>; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Anantpadma+M%22">Anantpadma M</searchLink>; Pfizer, 301 Middletown Road, Pearl River, NY 10965, USA.<br /><searchLink fieldCode="AU" term="%22Elkabbany+AH%22">Elkabbany AH</searchLink>; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, IN 47907, USA; Department of Chemistry, Massachusetts College of Liberal Arts, North Adams, MA 01247, USA.<br /><searchLink fieldCode="AU" term="%22Stubbs+SH%22">Stubbs SH</searchLink>; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Davisson+VJ%22">Davisson VJ</searchLink>; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, IN 47907, USA.<br /><searchLink fieldCode="AU" term="%22Davey+RA%22">Davey RA</searchLink>; Department of Virology, Immunology and Microbiology, Chobanian & Avedisian School of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA 02118, USA. Electronic address: radavey@bu.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101697563%22">SLAS discovery : advancing life sciences R & D</searchLink> [SLAS Discov] 2026 Sep; Vol. 42, pp. 100319. <i>Date of Electronic Publication: </i>2026 Jun 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101697563 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2472-5560 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2224725552%22">24725552 </searchLink><i>NLM ISO Abbreviation: </i>SLAS Discov <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42285356 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.slasd.2026.100319 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 100319 Titles: – TitleFull: In silico prioritization and cheminformatics identify structurally diverse small-molecule inhibitors of Lassa virus glycoprotein-mediated membrane fusion. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Close BJ – PersonEntity: Name: NameFull: La Rosa B – PersonEntity: Name: NameFull: Ong C – PersonEntity: Name: NameFull: Anantpadma M – PersonEntity: Name: NameFull: Elkabbany AH – PersonEntity: Name: NameFull: Stubbs SH – PersonEntity: Name: NameFull: Davisson VJ – PersonEntity: Name: NameFull: Davey RA IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: 2026 Sep Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2472-5560 Numbering: – Type: volume Value: 42 Titles: – TitleFull: SLAS discovery : advancing life sciences R & D Type: main |
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