pH-dependent activation of the Na+/H+ antiporter NhaA and conformational dynamics of its N-terminus.

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Title: pH-dependent activation of the Na+/H+ antiporter NhaA and conformational dynamics of its N-terminus.
Authors: Weng TH; Emeritus Group Molecular Membrane Biology, Max Planck Institute of Biophysics, Frankfurt, Germany., Fábián B; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt, Germany., Olkhova E; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt, Germany., Welsch S; Central Electron Microscopy Facility, Max Planck Institute of Biophysics, Frankfurt, Germany., Schmidt SL; Emeritus Group Molecular Membrane Biology, Max Planck Institute of Biophysics, Frankfurt, Germany.; Center for Life Sciences, Paul Scherrer Institute, Villigen PSI, Würenlingen, Switzerland., Danieli T; The Protein Production Facility, Alexander Silberman Institute of Life Sciences, the Hebrew University of Jerusalem, Jerusalem, Israel., Keren Y; The Protein Production Facility, Alexander Silberman Institute of Life Sciences, the Hebrew University of Jerusalem, Jerusalem, Israel., Rimon A; Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, the Hebrew University of Jerusalem, Jerusalem, Israel., Safarian S; Emeritus Group Molecular Membrane Biology, Max Planck Institute of Biophysics, Frankfurt, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Frankfurt, Frankfurt, Germany.; Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Frankfurt, Germany.; Institute of Clinical Pharmacology, Goethe University Frankfurt, Frankfurt, Germany., Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt, Germany.; Institute of Biophysics, Goethe University Frankfurt, Frankfurt, Germany., Padan E; Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, the Hebrew University of Jerusalem, Jerusalem, Israel. etana.padan@mail.huji.ac.il., Michel H; Emeritus Group Molecular Membrane Biology, Max Planck Institute of Biophysics, Frankfurt, Germany. hartmut.michel@biophys.mpg.de.
Source: Nature communications [Nat Commun] 2026 Jun 12. Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-73424-2