Acute pretrauma ethanol exacerbates PTSD-like phenotype in rats and is reversed by early intranasal ketamine.

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Title: Acute pretrauma ethanol exacerbates PTSD-like phenotype in rats and is reversed by early intranasal ketamine.
Authors: Yogev BE; Department of Psychology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.; Anxiety and Stress Research Unit, Ministry of Health, Be'erot Mental Health Center, Beer-Sheva, Israel., Levi G; Department of Psychology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.; Anxiety and Stress Research Unit, Ministry of Health, Be'erot Mental Health Center, Beer-Sheva, Israel., Efroni N; Anxiety and Stress Research Unit, Ministry of Health, Be'erot Mental Health Center, Beer-Sheva, Israel., Sintov AC; Department of Biomedical Engineering, Faculty of Engineering Sciences, Ben- Gurion University of the Negev, Beer-Sheva, Israel., Todder D; Anxiety and Stress Research Unit, Ministry of Health, Be'erot Mental Health Center, Beer-Sheva, Israel.; Faculty of Health Sciences, Ben-Gurion University of the Negev, P. O. Box 4600, 84170, Beer-Sheva, Israel., Zohar J; Post-Trauma Center, Sheba Medical Center, Tel Aviv University, Tel Aviv, 52621, Israel., Cohen H; Department of Psychology, Ben-Gurion University of the Negev, Beer-Sheva, Israel. hagitc@bgu.ac.il.; Anxiety and Stress Research Unit, Ministry of Health, Be'erot Mental Health Center, Beer-Sheva, Israel. hagitc@bgu.ac.il.; Faculty of Health Sciences, Ben-Gurion University of the Negev, P. O. Box 4600, 84170, Beer-Sheva, Israel. hagitc@bgu.ac.il.
Source: Scientific reports [Sci Rep] 2026 Jun 14. Date of Electronic Publication: 2026 Jun 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-026-56757-2