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Timing of device-aided therapy initiation in Parkinson's disease: reference estimates for healthcare planning and biological heterogeneity.

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Title: Timing of device-aided therapy initiation in Parkinson's disease: reference estimates for healthcare planning and biological heterogeneity.
Authors: Ledingham D; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.; Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK., Stewart CB; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK., Sathyanarayana S; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK., Foster V; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom., Iredale R; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom., Galley D; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom., Baker MR; Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK., Pavese N; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.; Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom.; Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK.
Source: Clinical parkinsonism & related disorders [Clin Park Relat Disord] 2026 Jun 04; Vol. 14, pp. 100458. Date of Electronic Publication: 2026 Jun 04 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101761473 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-1125 (Electronic) Linking ISSN: 25901125 NLM ISO Abbreviation: Clin Park Relat Disord Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ledingham+D%22">Ledingham D</searchLink>; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.; Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Stewart+CB%22">Stewart CB</searchLink>; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Sathyanarayana+S%22">Sathyanarayana S</searchLink>; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Foster+V%22">Foster V</searchLink>; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Iredale+R%22">Iredale R</searchLink>; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Galley+D%22">Galley D</searchLink>; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Baker+MR%22">Baker MR</searchLink>; Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Pavese+N%22">Pavese N</searchLink>; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.; Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom.; Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK.
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  Data: <searchLink fieldCode="JN" term="%22101761473%22">Clinical parkinsonism & related disorders</searchLink> [Clin Park Relat Disord] 2026 Jun 04; Vol. 14, pp. 100458. <i>Date of Electronic Publication: </i>2026 Jun 04 (<i>Print Publication: </i>2026).
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        Value: 10.1016/j.prdoa.2026.100458
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              Text: 2026 Jun 04
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