Loss of the ER-cargo protein CLN8 increases severity of acute pancreatitis and upregulates ER-stress and ER-phagy.

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Title: Loss of the ER-cargo protein CLN8 increases severity of acute pancreatitis and upregulates ER-stress and ER-phagy.
Authors: Zierke L; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany., Gischke M; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany., Sendler M; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany., Weiss FU; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany., Ribback S; Department of Pathology, University Medicine Greifswald, Greifswald, Germany., Skowronek D; Department of Human Genetics, University Medicine and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany., Rath M; Department of Human Genetics, University Medicine and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.; Institute for Molecular Medicine, MSH Medical School Hamburg, Hamburg, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Lerch MM; Ludwig-Maximilians University Munich, Munich, Germany., Aghdassi AA; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany. ali.aghdassi@med.uni-greifswald.de.
Source: Molecular biomedicine [Mol Biomed] 2026 Jun 15; Vol. 7 (1). Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2662-8651
DOI:10.1186/s43556-026-00479-4