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Loss of the ER-cargo protein CLN8 increases severity of acute pancreatitis and upregulates ER-stress and ER-phagy.

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Title: Loss of the ER-cargo protein CLN8 increases severity of acute pancreatitis and upregulates ER-stress and ER-phagy.
Authors: Zierke L; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany., Gischke M; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany., Sendler M; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany., Weiss FU; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany., Ribback S; Department of Pathology, University Medicine Greifswald, Greifswald, Germany., Skowronek D; Department of Human Genetics, University Medicine and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany., Rath M; Department of Human Genetics, University Medicine and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.; Institute for Molecular Medicine, MSH Medical School Hamburg, Hamburg, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Lerch MM; Ludwig-Maximilians University Munich, Munich, Germany., Aghdassi AA; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany. ali.aghdassi@med.uni-greifswald.de.
Source: Molecular biomedicine [Mol Biomed] 2026 Jun 15; Vol. 7 (1). Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Loss of the ER-cargo protein CLN8 increases severity of acute pancreatitis and upregulates ER-stress and ER-phagy.
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  Data: <searchLink fieldCode="AU" term="%22Zierke+L%22">Zierke L</searchLink>; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Gischke+M%22">Gischke M</searchLink>; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Sendler+M%22">Sendler M</searchLink>; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Weiss+FU%22">Weiss FU</searchLink>; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Ribback+S%22">Ribback S</searchLink>; Department of Pathology, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Skowronek+D%22">Skowronek D</searchLink>; Department of Human Genetics, University Medicine and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Rath+M%22">Rath M</searchLink>; Department of Human Genetics, University Medicine and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.; Institute for Molecular Medicine, MSH Medical School Hamburg, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Völzke+H%22">Völzke H</searchLink>; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Lerch+MM%22">Lerch MM</searchLink>; Ludwig-Maximilians University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Aghdassi+AA%22">Aghdassi AA</searchLink>; Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str., 17475, Greifswald, Germany. ali.aghdassi@med.uni-greifswald.de.
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  Data: <searchLink fieldCode="JN" term="%229918283581406676%22">Molecular biomedicine</searchLink> [Mol Biomed] 2026 Jun 15; Vol. 7 (1). <i>Date of Electronic Publication: </i>2026 Jun 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Singapore%22">Springer Singapore </searchLink><i>Country of Publication: </i>Singapore <i>NLM ID: </i>9918283581406676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-8651 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226628651%22">26628651 </searchLink><i>NLM ISO Abbreviation: </i>Mol Biomed <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s43556-026-00479-4
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        Text: English
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              Text: 2026 Jun 15
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