A myeloid immunosuppressive phenotype defines primary refractoriness to atezolizumab plus bevacizumab in hepatocellular carcinoma.

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Title: A myeloid immunosuppressive phenotype defines primary refractoriness to atezolizumab plus bevacizumab in hepatocellular carcinoma.
Authors: Lombardi P; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK; Phase 1 Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy., Ramon-Gil E; The Newcastle University Centre for Cancer, Newcastle University, Newcastle Upon Tyne, U.K., Raja RQ; The Newcastle University Centre for Cancer, Newcastle University, Newcastle Upon Tyne, U.K., Brunetti L; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK., Manfredi GF; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK; Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy., Zhou Z; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK., Merces G; Image Analysis Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Cappuyns S; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK; Digestive Oncology, Department of Gastroenterology and Hepatology, UZ/KU Leuven, Belgium., Fulgenzi CAM; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK., D'Alessio A; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK., Torkpour A; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK., Celsa C; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK; Section of Gastroenterology & Hepatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy., Stefanini B; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK; Department of Medical and Surgical Sciences, University of Bologna, Italy., Yang H; Medical Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea., Crowley F; Department of Medicine, Division of Hematology/Oncology, Tisch Cancer Institute, Mount Sinai Hospital, New York, NY, USA., Marron TU; Department of Medicine, Division of Hematology/Oncology, Tisch Cancer Institute, Mount Sinai Hospital, New York, NY, USA., Saeed A; Department of Medicine, Division of Hematology & Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Pinter M; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Scheiner B; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Huang YH; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lee PC; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Nishida N; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan., Po-Ting Lin R; Department of Gastroenterology and Hepatology, Chang Gung Medical Foundation, Linkou Chang Gung Memorial Hospital, Taiwan NO 5, Fu-Hsing Street, Kuei Shan, Taoyuan 333, Taiwan., Dalbeni A; University of Verona, Department of Medicine General Medicine C Unit & Liver Unit., Vivaldi C; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy., Masi G; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy., Rohlen N; Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, University of Freiburg, Freiburg, Germany., von Felden J; Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kaseb A; Gastrointestinal Medical Oncology Department, University of Texas MD Anderson Cancer Center, Houston, TX., Galle PR; University Medical Center Mainz, I. Dept. of Internal Medicine, Mainz, Germany., Kudo M; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan., Hsu WF; Department of Internal Medicine, Center for Digestive Medicine, China Medical University Hospital, Taichung, Taiwan., Rimassa L; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy; Hepatopancreatobiliary Oncology , Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Via A. Manzoni 56, 20089 Rozzano, Milan, Italy., Parisi A; Department of Oncology, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria delle Marche, Ancona, Italy., Kelley RK; Department of Medicine (Hematology/Oncology), UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA., Toyoda H; Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan., Pirisi M; Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy., Jabar F; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK; Department of Clinical Pathology, University Hospital of North Norway, Tromsø, Norway., Rakaee M; Department of Clinical Pathology, University Hospital of North Norway, Tromsø, Norway; Department of Cancer Genetics, Oslo University Hospital, Oslo, Norway; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Medical Biology, UiT The Arctic University of Norway, Tromsø, Norway., Cabibbo G; Section of Gastroenterology & Hepatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy; Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Italy., Cammà C; Section of Gastroenterology & Hepatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, Italy., Piscaglia F; Department of Medical and Surgical Sciences, University of Bologna, Italy; Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy., Hwang S; Department of Pathology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea., Shin DJ; Department of Biomedical Science, College of Life Science, CHA University School of Medicine, Seongnam, Republic of Korea., Li M; Division of Gastroenterology and Hepatology, University of California, San Francisco, California, USA., Dekervel J; Digestive Oncology, Department of Gastroenterology and Hepatology, UZ/KU Leuven, Belgium., Guerra N; Department of Life Sciences, Imperial College London, South Kensington Campus, Exhibition Road, London, SW7 2AZ, UK., Meyer T; Research Department of Oncology, UCL Cancer Institute, University College London, Royal Free Hospital, London, UK., Reeves HL; The Newcastle University Centre for Cancer, Newcastle University, Newcastle Upon Tyne, U.K; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK; NIHR, Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK., Bengsch B; Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, University of Freiburg, Freiburg, Germany., Daniele G; Phase 1 Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy., Mann DA; The Newcastle University Centre for Cancer, Newcastle University, Newcastle Upon Tyne, U.K., Chon HJ; Medical Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea. Electronic address: minidoctor@cha.ac.kr., Leslie J; The Newcastle University Centre for Cancer, Newcastle University, Newcastle Upon Tyne, U.K; NIHR, Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK. Electronic address: Jack.Leslie@newcastle.ac.uk., Pinato DJ; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK; Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy. Electronic address: david.pinato@imperial.ac.uk.
Source: Journal of hepatology [J Hepatol] 2026 Jun 15. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1600-0641
DOI:10.1016/j.jhep.2026.05.018