Targeting the senescence‒autophagy axis via p16INK4a inhibition alleviates pulmonary fibrosis.

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Title: Targeting the senescence‒autophagy axis via p16INK4a inhibition alleviates pulmonary fibrosis.
Authors: Yoo YJ; Graduate School of Pharmaceutical Sciences and College of Pharmacy, Seoul, Republic of Korea., Zhang M; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea., Jin SH; Innovative BioPharmChem Convergence Education and Research Program, Ewha Womans University, Seoul, Republic of Korea., Lee YR; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea., Jin H; Graduate School of Pharmaceutical Sciences and College of Pharmacy, Seoul, Republic of Korea., Doan TP; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea., Kim S; Graduate School of Pharmaceutical Sciences and College of Pharmacy, Seoul, Republic of Korea., Choi S; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea., Park EJ; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Sookmyung Women's University, Seoul, Republic of Korea., Na S; Innovative BioPharmChem Convergence Education and Research Program, Ewha Womans University, Seoul, Republic of Korea., Lee Y; Innovative BioPharmChem Convergence Education and Research Program, Ewha Womans University, Seoul, Republic of Korea., Sun J; Innovative BioPharmChem Convergence Education and Research Program, Ewha Womans University, Seoul, Republic of Korea., Cho J; Department of Radiation Oncology, Yonsei University Health System, Seoul, Republic of Korea., Cho NC; Drug Information Platform Center, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea., Park SY; Graduate School of Pharmaceutical Sciences and College of Pharmacy, Seoul, Republic of Korea. syeonp@ewha.ac.kr., Oh WK; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea. wkoh1@snu.ac.kr., Lee YS; Graduate School of Pharmaceutical Sciences and College of Pharmacy, Seoul, Republic of Korea. yslee0425@ewha.ac.kr.; Innovative BioPharmChem Convergence Education and Research Program, Ewha Womans University, Seoul, Republic of Korea. yslee0425@ewha.ac.kr.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 15; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2059-3635
DOI:10.1038/s41392-026-02730-4