Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium.

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Title: Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium.
Authors: Fam KT; Department of Immunology and Microbiology, Scripps Research; La Jolla, CA, USA., Chodisetti PK; Department of Immunology and Microbiology, Scripps Research; La Jolla, CA, USA., Wang Z; Cancer Center, Cold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA., Homer JA; Cancer Center, Cold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA., Smedley CJ; La Trobe Institute for Molecular Science, La Trobe University, Science Dr., Bundoora, Melbourne, VIC, Australia., Kitamura S; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.; Department of Molecular Medicine, Scripps Research; La Jolla, CA, USA.; Department of Chemistry, Scripps Research; La Jolla, CA, USA., Silva B; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Xiong Y; Department of Chemistry, Scripps Research; La Jolla, CA, USA., Hansel-Harris A; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Holcomb M; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Babarinde S; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Turner AM; Department of Immunology and Microbiology, Scripps Research; La Jolla, CA, USA., Van Tyne D; Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wilson IA; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Forli S; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Cravatt BF; Department of Chemistry, Scripps Research; La Jolla, CA, USA., Park D; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Wolan DW; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.; Department of Molecular Medicine, Scripps Research; La Jolla, CA, USA., Moses JE; Cancer Center, Cold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA. moses@cshl.edu.; La Trobe Institute for Molecular Science, La Trobe University, Science Dr., Bundoora, Melbourne, VIC, Australia. moses@cshl.edu., Hang HC; Department of Immunology and Microbiology, Scripps Research; La Jolla, CA, USA. hhang@scripps.edu.; Department of Chemistry, Scripps Research; La Jolla, CA, USA. hhang@scripps.edu.
Source: Nature communications [Nat Commun] 2026 Jun 16. Date of Electronic Publication: 2026 Jun 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-74057-1