Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium.
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| Title: | Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium. |
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| Authors: | Fam KT; Department of Immunology and Microbiology, Scripps Research; La Jolla, CA, USA., Chodisetti PK; Department of Immunology and Microbiology, Scripps Research; La Jolla, CA, USA., Wang Z; Cancer Center, Cold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA., Homer JA; Cancer Center, Cold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA., Smedley CJ; La Trobe Institute for Molecular Science, La Trobe University, Science Dr., Bundoora, Melbourne, VIC, Australia., Kitamura S; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.; Department of Molecular Medicine, Scripps Research; La Jolla, CA, USA.; Department of Chemistry, Scripps Research; La Jolla, CA, USA., Silva B; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Xiong Y; Department of Chemistry, Scripps Research; La Jolla, CA, USA., Hansel-Harris A; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Holcomb M; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Babarinde S; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Turner AM; Department of Immunology and Microbiology, Scripps Research; La Jolla, CA, USA., Van Tyne D; Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wilson IA; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Forli S; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Cravatt BF; Department of Chemistry, Scripps Research; La Jolla, CA, USA., Park D; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA., Wolan DW; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.; Department of Molecular Medicine, Scripps Research; La Jolla, CA, USA., Moses JE; Cancer Center, Cold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA. moses@cshl.edu.; La Trobe Institute for Molecular Science, La Trobe University, Science Dr., Bundoora, Melbourne, VIC, Australia. moses@cshl.edu., Hang HC; Department of Immunology and Microbiology, Scripps Research; La Jolla, CA, USA. hhang@scripps.edu.; Department of Chemistry, Scripps Research; La Jolla, CA, USA. hhang@scripps.edu. |
| Source: | Nature communications [Nat Commun] 2026 Jun 16. Date of Electronic Publication: 2026 Jun 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42297812 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Fam+KT%22">Fam KT</searchLink>; Department of Immunology and Microbiology, Scripps Research; La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chodisetti+PK%22">Chodisetti PK</searchLink>; Department of Immunology and Microbiology, Scripps Research; La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Cancer Center, Cold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Homer+JA%22">Homer JA</searchLink>; Cancer Center, Cold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Smedley+CJ%22">Smedley CJ</searchLink>; La Trobe Institute for Molecular Science, La Trobe University, Science Dr., Bundoora, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kitamura+S%22">Kitamura S</searchLink>; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.; Department of Molecular Medicine, Scripps Research; La Jolla, CA, USA.; Department of Chemistry, Scripps Research; La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Silva+B%22">Silva B</searchLink>; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Department of Chemistry, Scripps Research; La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hansel-Harris+A%22">Hansel-Harris A</searchLink>; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Holcomb+M%22">Holcomb M</searchLink>; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Babarinde+S%22">Babarinde S</searchLink>; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Turner+AM%22">Turner AM</searchLink>; Department of Immunology and Microbiology, Scripps Research; La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Van+Tyne+D%22">Van Tyne D</searchLink>; Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+IA%22">Wilson IA</searchLink>; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Forli+S%22">Forli S</searchLink>; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Cravatt+BF%22">Cravatt BF</searchLink>; Department of Chemistry, Scripps Research; La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Park+D%22">Park D</searchLink>; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Wolan+DW%22">Wolan DW</searchLink>; Department of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California, USA.; Department of Molecular Medicine, Scripps Research; La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Moses+JE%22">Moses JE</searchLink>; Cancer Center, Cold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA. moses@cshl.edu.; La Trobe Institute for Molecular Science, La Trobe University, Science Dr., Bundoora, Melbourne, VIC, Australia. moses@cshl.edu.<br /><searchLink fieldCode="AU" term="%22Hang+HC%22">Hang HC</searchLink>; Department of Immunology and Microbiology, Scripps Research; La Jolla, CA, USA. hhang@scripps.edu.; Department of Chemistry, Scripps Research; La Jolla, CA, USA. hhang@scripps.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jun 16. <i>Date of Electronic Publication: </i>2026 Jun 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42297812 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-026-74057-1 Languages: – Code: eng Text: English Titles: – TitleFull: Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fam KT – PersonEntity: Name: NameFull: Chodisetti PK – PersonEntity: Name: NameFull: Wang Z – PersonEntity: Name: NameFull: Homer JA – PersonEntity: Name: NameFull: Smedley CJ – PersonEntity: Name: NameFull: Kitamura S – PersonEntity: Name: NameFull: Silva B – PersonEntity: Name: NameFull: Xiong Y – PersonEntity: Name: NameFull: Hansel-Harris A – PersonEntity: Name: NameFull: Holcomb M – PersonEntity: Name: NameFull: Babarinde S – PersonEntity: Name: NameFull: Turner AM – PersonEntity: Name: NameFull: Van Tyne D – PersonEntity: Name: NameFull: Wilson IA – PersonEntity: Name: NameFull: Forli S – PersonEntity: Name: NameFull: Cravatt BF – PersonEntity: Name: NameFull: Park D – PersonEntity: Name: NameFull: Wolan DW – PersonEntity: Name: NameFull: Moses JE – PersonEntity: Name: NameFull: Hang HC IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 06 Text: 2026 Jun 16 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-1723 Titles: – TitleFull: Nature communications Type: main |
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